Clinical Outcomes of the Lund, Toronto, and Organ Care System Protocols for Normothermic Ex Vivo Lung Perfusion: A Systematic Review and Pursuit of Network Meta-Analysis
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DOI: 10.1016/j.healun.2021.01.874
Abstract: Purpose Ex Vivo Lung Perfusion (EVLP) is an excellent method to preserve and recondition donor lungs, thus increasing the lung donor pool. This systematic review summarizes studies comparing both primary graft dysfunction (PGD) and survival… read more here.
Keywords: evlp protocols; lung; vivo lung; systematic review ... See more keywords
Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in vivo lung chemo-perfusion
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DOI: 10.1016/j.jpha.2020.08.011
Abstract: Development of a novel in vivo lung perfusion (IVLP) procedure allows localized delivery of high-dose doxorubicin (DOX) for targeting residual micrometastatic disease in the lungs. However, DOX delivery via IVLP requires careful monitoring of drug… read more here.
Keywords: bio spme; perfusion; chemical biopsy; vivo lung ... See more keywords
A Low-Cost Perfusate Alternative for Ex Vivo Lung Perfusion.
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DOI: 10.1016/j.transproceed.2020.05.007
Abstract: BACKGROUND Normothermic ex vivo lung perfusion (EVLP) has been used successfully to evaluate and recondition marginal donor lungs; however, multiple barriers continue to prevent its widespread adoption. We sought to develop a common hospital ingredient-derived perfusate… read more here.
Keywords: lung perfusion; perfusion; khb alb; vivo lung ... See more keywords
Ligand free FeSn2 alloy nanoparticles for safe T2-weighted MR imaging of in vivo lung tumors.
Sign Up to like & getrecommendations! Published in 2023 at "Biomaterials science"
DOI: 10.1039/d2bm01517j
Abstract: Biosafety is a critical issue for the successful translocation of nanomaterial-based therapeutic/diagnostic agents from bench to bedside. For instance, after the withdrawal of clinically approved magnetic resonance (MR) imaging contrast agents (CAs) due to their… read more here.
Keywords: ligand free; vivo lung; fesn2 alloy; free fesn2 ... See more keywords
Biometric Profiling to Quantify Lung Injury Through Ex Vivo Lung Perfusion Following Warm Ischemia.
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DOI: 10.1097/mat.0000000000001988
Abstract: Standard physiologic assessment parameters of donor lung grafts may not accurately reflect lung injury or quality. A biometric profile of ischemic injury could be identified as a means to assess the quality of the donor… read more here.
Keywords: lung injury; ischemic injury; lung; vivo lung ... See more keywords
Ex-vivo lung perfusion therapies: do they add value to organ donation?
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DOI: 10.1097/mot.0000000000000961
Abstract: Purpose of review Significant limitations in organ availability and postoperative graft dysfunction plague lung transplantation and there is continual need for innovation. Ex-vivo lung perfusion (EVLP) has emerged over the last decade as an alternative… read more here.
Keywords: lung transplantation; lung; vivo lung; value ... See more keywords
Diagnostic and Therapeutic Implications of Ex Vivo Lung Perfusion in Lung Transplantation: Potential Benefits and Inherent Limitations
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DOI: 10.1097/tp.0000000000004414
Abstract: Ex vivo lung perfusion (EVLP), a technique in which isolated lungs are continually ventilated and perfused at normothermic temperature, is emerging as a promising platform to optimize donor lung quality and increase the lung graft… read more here.
Keywords: lung transplantation; lung; vivo lung; transplantation ... See more keywords
Modeling the Effects of IL-1β-mediated Inflammation During Ex Vivo Lung Perfusion Using a Split Human Donor Model.
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DOI: 10.1097/tp.0000000000004613
Abstract: BACKGROUND The association between interleukin-1β (IL-1β) concentrations during ex vivo lung perfusion (EVLP) with donor organ quality and post-lung transplant outcome has been demonstrated in several studies. The mechanism underlying IL-1β-mediated donor lung injury was… read more here.
Keywords: donor; lung; vivo lung; model ... See more keywords
Treatment with 3‐aminobenzamide during ex vivo lung perfusion of damaged rat lungs reduces graft injury and dysfunction after transplantation
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DOI: 10.1111/ajt.15695
Abstract: Ex vivo lung perfusion (EVLP) with pharmacological reconditioning may increase donor lung utilization for transplantation (LTx). 3‐Aminobenzamide (3‐AB), an inhibitor of poly(ADP‐ribose) polymerase (PARP), reduces ex vivo lung injury in rat lungs damaged by warm… read more here.
Keywords: lung perfusion; rat lungs; transplantation; vivo lung ... See more keywords
Lung transplantation after ex vivo lung perfusion versus static cold storage: An institutional cost analysis
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DOI: 10.1111/ajt.16794
Abstract: Ex vivo lung perfusion (EVLP) is a novel lung preservation strategy that facilitates the use of marginal allografts; however, it is more expensive than static cold storage (SCS). To understand how preservation method might affect… read more here.
Keywords: lung; evlp; vivo lung; scd ... See more keywords
Establishing an economical and widely accessible donation after circulatory death animal abattoir model for lung research using ex vivo lung perfusion
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DOI: 10.1111/aor.14345
Abstract: Abstract Background Ex vivo lung perfusion (EVLP), is a platform that allows simultaneous testing and treatment of the lungs. However, use of EVLP is costly and requires access to lab animals and accompanying facilities. To… read more here.
Keywords: lung; vivo lung; perfusion; abattoir model ... See more keywords