Microscopic and biochemical monitoring of endosomal trafficking and extracellular vesicle secretion in an endogenous in vivo model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12263
Abstract: Abstract Extracellular vesicle (EV) secretion enables cell–cell communication in multicellular organisms. During development, EV secretion and the specific loading of signalling factors in EVs contributes to organ development and tissue differentiation. Here, we present an… read more here.
Keywords: vivo model; vivo; extracellular vesicle; secretion ... See more keywords
Precision cut lung slices: an ex vivo model for assessing the impact of immunomodulatory therapeutics on lung immune responses.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of toxicology"
DOI: 10.1007/s00204-021-03096-y
Abstract: Chronic inflammatory diseases of the respiratory tract, such as chronic obstructive pulmonary disease (COPD) and asthma, are severe lung diseases that require effective treatments. In search for new medicines for these diseases, there is an… read more here.
Keywords: cut lung; precision cut; vivo model; lung slices ... See more keywords
Determination of initial airtightness after anatomical laser segmentectomy in an ex vivo model
Sign Up to like & getrecommendations! Published in 2021 at "Lasers in Medical Science"
DOI: 10.1007/s10103-021-03312-2
Abstract: If a pulmonary pathology can be removed by anatomical segmentectomy, the need for lobectomy is obviated. The procedure is considered oncologically equivalent and saves healthy lung tissue. In every segmentectomy, lung parenchyma must be transected… read more here.
Keywords: segmentectomy; determination initial; laser; vivo model ... See more keywords
A technical protocol for an experimental ex vivo model using arterially perfused porcine eyes
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2019.02.003
Abstract: ABSTRACT Ex vivo ocular perfused models have been described in the past and were applied in different mammalian species as platforms to test drug delivery systems and surgical techniques. However, reproduction of those methods is… read more here.
Keywords: experimental vivo; vivo; vivo model; technical protocol ... See more keywords
Human peripheral blood mononuclear cells as an ex vivo model to study the host parasite interaction in Toxoplasma gondii.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental parasitology"
DOI: 10.1016/j.exppara.2020.108020
Abstract: Toxoplasma gondii is a parasite that can invade any cell in the human body. Here, we implemented and described an ex vivo model with human peripheral blood mononuclear cells (PBMCs) without using culture supplements/antibiotics and… read more here.
Keywords: pbmcs; infection; gondii; vivo model ... See more keywords
Collaborative Virtual Screening Identifies a 2-Aryl-4-aminoquinazoline Series with Efficacy in an In Vivo Model of Trypanosoma cruzi Infection
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00775
Abstract: Probing multiple proprietary pharmaceutical libraries in parallel via virtual screening allowed rapid expansion of the structure–activity relationship (SAR) around hit compounds with moderate efficacy against Trypanosoma cruzi, the causative agent of Chagas Disease. A potency-improving… read more here.
Keywords: vivo model; cruzi infection; virtual screening; trypanosoma cruzi ... See more keywords
Erratum: An in vivo model of functional and vascularized human brain organoids
Sign Up to like & getrecommendations! Published in 2018 at "Nature Biotechnology"
DOI: 10.1038/nbt0818-772e
Abstract: Nat. Biotechnol. 36, 432–441 (2018); published online 16 April 2018; corrected after print 18 July 2018 In the version of this article initially published, credit for part of Figure 4a was omitted. The image of… read more here.
Keywords: functional vascularized; model functional; vivo model; erratum vivo ... See more keywords
An ex vivo model of medical device-mediated bacterial skin translocation
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-84826-1
Abstract: The skin is a barrier and part of the immune system that protects us from harmful bacteria. Because indwelling medical devices break this barrier, they greatly increase the risk of infection by microbial pathogens. To… read more here.
Keywords: skin; vivo model; model medical; translocation ... See more keywords
EX VIVO MODEL FOR THE CHARACTERIZATION AND IDENTIFICATION OF DRYWALL INTRAOCULAR FOREIGN BODIES ON COMPUTED TOMOGRAPHY
Sign Up to like & getrecommendations! Published in 2018 at "Retina"
DOI: 10.1097/iae.0000000000001731
Abstract: Background: The study was inspired after the authors encountered a patient with a penetrating globe injury due to drywall, who had retained intraocular drywall foreign body. Computed tomography (CT) was read as normal in this… read more here.
Keywords: computed tomography; foreign body; vivo model; intraocular drywall ... See more keywords
THU0336 DEVELOPING A NOVEL RAPID EX VIVO MODEL OF SKIN FIBROSIS FOR SYSTEMIC SCLEROSIS RESEARCH
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.1881
Abstract: Background Systemic Sclerosis (SSc) is an autoimmune disease that causes tissue fibrosis in multiple systems. Immune dysfunction and dysregulation are known to play a role in the disease, but the pathophysiology of SSc is not… read more here.
Keywords: collagen; fibrosis; vivo model; skin fibrosis ... See more keywords
Abstract B35: An innovative in vivo model of metastasizing prostate cancer using orthotopic xenografts
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.mousemodels17-b35
Abstract: Introduction: In this study, we aimed to develop a versatile in vivo model of prostate cancer using orthotopic xenografts, which adequately represents intraprostatic tumor growth as well as the natural routes of metastatic spread. Materials… read more here.
Keywords: using orthotopic; orthotopic xenografts; prostate cancer; vivo model ... See more keywords