A Closed-Circuit Ex Vivo Perfusion System for Pediatric Solid Organ Transplantation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Heart and Lung Transplantation"
DOI: 10.1016/j.healun.2021.01.1834
Abstract: Purpose Donation after cardiac death and ex-vivo organ perfusion are increasingly used strategies to mitigate donor organ shortage in cardiac transplantation. These concepts have mainly been established in adults, while neglecting the specific needs for… read more here.
Keywords: closed circuit; system; perfusion; vivo perfusion ... See more keywords
Investigation of the influence of xenoreactive antibodies on activation of complement and coagulation in an ex vivo perfusion animal study using porcine kidneys
Sign Up to like & getrecommendations! Published in 2019 at "Transplant International"
DOI: 10.1111/tri.13396
Abstract: During pig‐to‐primate xenotransplantation or perfusion of porcine organs with human blood, a xenogeneic coagulopathy with consecutive development of thrombotic microangiopathy (TMA) can be observed. The aim of this study was to elucidate the influence of… read more here.
Keywords: coagulation; perfusion; vivo perfusion; activation ... See more keywords
Multiple genetically modified GTKO/hCD46/HLA‐E/hβ2−mg porcine hearts are protected from complement activation and natural killer cell infiltration during ex vivo perfusion with human blood
Sign Up to like & getrecommendations! Published in 2018 at "Xenotransplantation"
DOI: 10.1111/xen.12390
Abstract: In pig‐to‐human xenotransplantation, early cellular rejection reactions are mediated by natural killer cells (NK cells). Human NK cells are inhibited by HLA‐E via CD94/NKG2A receptors. To protect porcine grafts against human NK cell responses, transgenic… read more here.
Keywords: natural killer; human blood; vivo perfusion; cell ... See more keywords
Treatment of infected lungs by ex vivo perfusion with high dose antibiotics and autotransplantation: A pilot study in pigs
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0193168
Abstract: The emergence of multi-drug resistant bacteria threatens to end the era of antibiotics. Drug resistant bacteria have evolved mechanisms to overcome antibiotics at therapeutic doses and further dose increases are not possible due to systemic… read more here.
Keywords: pilot study; perfusion; high dose; treatment ... See more keywords