Enhanced non invasive trans-tympanic delivery of ciprofloxacin through encapsulation into nano-spanlastic vesicles: Fabrication, in-vitro characterization, and comparative ex-vivo permeation studies.
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DOI: 10.1016/j.ijpharm.2017.03.005
Abstract: The aim of this research was to encapsulate ciprofloxacin, a broad spectrum fluoroquinolone antibiotic, into Span 60 based nano-elastic vesicles, nano-spanlastics, for accomplishing improved non invasive trans-tympanic delivery, providing means for ototopical treatment of acute… read more here.
Keywords: trans tympanic; tympanic delivery; ciprofloxacin; nano spanlastic ... See more keywords
Nanoemulsion containing 8‐methoxypsoralen for topical treatment of dermatoses: Development, characterization and ex vivo permeation in porcine skin
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DOI: 10.1016/j.ijpharm.2018.05.053
Abstract: Graphical abstract Figure. No caption available. ABSTRACT Oral therapy with 8‐methoxypsoralen (8‐MOP) may cause major side effects, whereas the topical treatment might not be much effective due to the low penetration induced by typical formulations.… read more here.
Keywords: permeation; development characterization; skin; topical treatment ... See more keywords
Mucoadhesive buccal tablets containing silymarin Eudragit-loaded nanoparticles: formulation, characterisation and ex vivo permeation
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DOI: 10.1080/02652048.2017.1345996
Abstract: Abstract Eudragit-loaded silymarin nanoparticles (SNPs) and their formulation into buccal mucoadhesive tablets were investigated to improve the low bioavailability of silymarin through buccal delivery. Characterisation of SNPs and silymarin buccal tablets (SBTs) containing the optimised… read more here.
Keywords: permeation; formulation; buccal tablets; eudragit loaded ... See more keywords
Tri-block co-polymer nanocarriers for enhancement of oral delivery of felodipine: preparation, in vitro characterization and ex vivo permeation
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DOI: 10.1080/08982104.2017.1327541
Abstract: Abstract This study aimed to prepare, optimize and characterize novel felodipine-loaded polymeric nanomicelles, using a pluronic mixture of F127 and P123. Thin-film hydration method was adopted for the preparation of different polymeric nanomicelles (T1–T12) according… read more here.
Keywords: felodipine; oral delivery; permeation; polymer ... See more keywords
Clove Oil Endorsed Transdermal Flux of Dronedarone Hydrochloride Loaded Bilosomal Nanogel: Factorial Design, In vitro Evaluation and Ex vivo Permeation
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DOI: 10.1208/s12249-022-02337-2
Abstract: The goal of this study was to develop a bilosomal gel formulation to enhance transdermal permeability of dronedarone hyrdrochloride (DRN) which suffers from poor oral absorption and limited bioavailability. To overcome this obstacle, bilosomes were… read more here.
Keywords: factorial design; vivo permeation; clove oil; design ... See more keywords
Validation of an Ex Vivo Permeation Method for the Intestinal Permeability of Different BCS Drugs and Its Correlation with Caco-2 In Vitro Experiments
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DOI: 10.3390/pharmaceutics11120638
Abstract: The absorption study of drugs through different biological membranes constitutes an essential step in the development of new pharmaceutical dosage forms. Concerning orally administered forms, methods based on monolayer cell culture of Caco-2 (Caucasian colon… read more here.
Keywords: permeability; vivo permeation; correlation caco;