Proniosomal gel-derived niosomes: an approach to sustain and improve the ocular delivery of brimonidine tartrate; formulation, in-vitro characterization, and in-vivo pharmacodynamic study
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DOI: 10.1080/10717544.2019.1609622
Abstract: Abstract Brimonidine tartrate (BRT) is a hydrophilic α2 adrenergic agonist used for the treatment of glaucoma. Glaucoma is an ocular disease affecting the anterior segment of the eye requiring lifetime treatment. Owing to the obstacles… read more here.
Keywords: improve ocular; delivery; vivo pharmacodynamic; brimonidine tartrate ... See more keywords
In Vivo Pharmacodynamic Evaluation of Omadacycline (PTK 0796) against Streptococcus pneumoniae in the Murine Pneumonia Model
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DOI: 10.1128/aac.02368-16
Abstract: ABSTRACT Omadacycline is a novel aminomethylcycline antibiotic in clinical development for community-acquired bacterial pneumonia (CABP). We used a neutropenic murine pneumonia infection model to characterize the in vivo pharmacodynamic activity of omadacycline against Streptococcus pneumoniae.… read more here.
Keywords: auc mic; omadacycline; model; vivo pharmacodynamic ... See more keywords
In Vivo Pharmacodynamic and Pharmacokinetic Assessment of Cannabidiol-loaded Camel Milk Exosomes in Doxorubicin-resistant Triple-negative Breast Cancer Xenografts
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DOI: 10.1208/s12249-025-03201-9
Abstract: Cannabidiol (CBD) suffers from poor aqueous solubility and extensive first-pass metabolism, which significantly limits its oral bioavailability. In our earlier work, we developed camel milk-derived exosomes (CMDE) as nanocarriers to enhance CBD bioavailability, confirmed through… read more here.
Keywords: pharmacodynamic pharmacokinetic; cbd; vivo pharmacodynamic; camel milk ... See more keywords