In vivo pharmacokinetic and pharmacodynamic study of co-spray-dried inhalable pirfenidone microparticles in rats
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2149899
Abstract: Abstract Pirfenidone (PRF) is the first FDA-approved API in the treatment of idiopathic pulmonary fibrosis (IPF). However, PRF induces serious side effects, such as photophobia and gastrointestinal disorder. PRF inhalation can be expected with a… read more here.
Keywords: spray; pharmacodynamic study; spray dried; pharmacokinetic pharmacodynamic ... See more keywords
Preparation of sustained release apremilast-loaded PLGA nanoparticles: in vitro characterization and in vivo pharmacokinetic study in rats
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DOI: 10.2147/ijn.s195048
Abstract: Background Apremilast (APM) is a novel, orally administered small molecule drug approved for treatment of psoriasis or psoriatic arthritis. Due to its low solubility and permeability, it is classified as a class IV drug according… read more here.
Keywords: apremilast; vivo pharmacokinetic; plga nanoparticles; sustained release ... See more keywords