An “energy‐auxotroph” Escherichia coli provides an in vivo platform for assessing NADH regeneration systems
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27490
Abstract: An efficient in vivo regeneration of the primary cellular resources NADH and ATP is vital for optimizing the production of value‐added chemicals and enabling the activity of synthetic pathways. Currently, such regeneration routes are tested… read more here.
Keywords: vivo platform; nadh regeneration; escherichia coli; regeneration ... See more keywords
An in vivo platform to select and evolve aggregation-resistant proteins
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DOI: 10.1038/s41467-020-15667-1
Abstract: Protein biopharmaceuticals are highly successful, but their utility is compromised by their propensity to aggregate during manufacture and storage. As aggregation can be triggered by non-native states, whose population is not necessarily related to thermodynamic… read more here.
Keywords: vivo platform; aggregation; platform select; aggregation resistant ... See more keywords
The AVI-PDX: An innovative in vivo platform of miniaturized patient-derived xenografts for preclinical developments and personalized medicine.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e15607
Abstract: e15607Background: The conception of preclinical paradigms to predict the patient response is a major goal for the development of novel therapies and the design of personalized treatments in oncolog... read more here.
Keywords: vivo platform; medicine; pdx innovative; innovative vivo ... See more keywords