Design and Structural Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High In Vivo Potency and Oral Bioavailability.
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DOI: 10.1021/acs.jmedchem.2c02006
Abstract: Inhibition of methionine adenosyltransferase 2A (MAT2A) in cancers with a deletion of methylthioadenosine phosphorylase (MTAP) gene leads to synthetic lethality, thus receiving significant interest in the field of precise cancer treatment. Herein, we report the… read more here.
Keywords: vivo potency; methionine adenosyltransferase; potency; adenosyltransferase mat2a ... See more keywords