Injury-Induced Senescence Enables In Vivo Reprogramming in Skeletal Muscle.
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DOI: 10.1016/j.stem.2016.11.020
Abstract: In vivo reprogramming is a promising approach for tissue regeneration in response to injury. Several examples of in vivo reprogramming have been reported in a variety of lineages, but some including skeletal muscle have so far proven… read more here.
Keywords: vivo reprogramming; skeletal muscle; senescence; reprogramming skeletal ... See more keywords
Common Telomere Changes during In Vivo Reprogramming and Early Stages of Tumorigenesis
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DOI: 10.1016/j.stemcr.2017.01.001
Abstract: Summary Reprogramming of differentiated cells into induced pluripotent stem cells has been recently achieved in vivo in mice. Telomeres are essential for chromosomal stability and determine organismal life span as well as cancer growth. Here,… read more here.
Keywords: vivo reprogramming; changes vivo; reprogramming early; telomere changes ... See more keywords
AAV vector-mediated in vivo reprogramming into pluripotency
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DOI: 10.1038/s41467-018-05059-x
Abstract: In vivo reprogramming of somatic cells into induced pluripotent stem cells (iPSC) holds vast potential for basic research and regenerative medicine. However, it remains hampered by a need for vectors to express reprogramming factors (Oct-3/4,… read more here.
Keywords: vivo reprogramming; vector; vector mediated; aav vector ... See more keywords
In vivo reprogramming of wound-resident cells generates skin epithelial tissue
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DOI: 10.1038/s41586-018-0477-4
Abstract: Large cutaneous ulcers are, in severe cases, life threatening1,2. As the global population ages, non-healing ulcers are becoming increasingly common1,2. Treatment currently requires the transplantation of pre-existing epithelial components, such as skin grafts, or therapy… read more here.
Keywords: vivo reprogramming; wound resident; skin epithelial; reprogramming wound ... See more keywords
Senescence promotes in vivo reprogramming through p16INK 4a and IL‐6
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DOI: 10.1111/acel.12711
Abstract: Cellular senescence is a damage response aimed to orchestrate tissue repair. We have recently reported that cellular senescence, through the paracrine release of interleukin‐6 (IL6) and other soluble factors, strongly favors cellular reprogramming by Oct4,… read more here.
Keywords: vivo reprogramming; senescence promotes; il6; senescence ... See more keywords