An Evaluation of the in vivo Safety of Nonporous Silica Nanoparticles: Ocular Topical Administration versus Oral Administration
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DOI: 10.1038/s41598-017-08843-9
Abstract: Nonporous silica nanoparticles (SiNPs) have potential as promising carriers for ophthalmic drugs. However, the in vivo safety of ocular topical SiNPs remains unclear. This study investigated the in vivo safety of oral and ocular topical… read more here.
Keywords: vivo safety; administration; sinps; ocular topical ... See more keywords
Preparation and in vivo safety evaluations of antileukemic homoharringtonine-loaded PEGylated liposomes
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DOI: 10.1080/03639045.2016.1275670
Abstract: Abstract In order to improve the in vivo safety and specific delivery efficiency of the antileukemic homoharringtonine (HHT) at the targets, the long-circulating PEGylated liposomes loaded with HHT (LCLipo-HHT) were prepared. Their physical characteristics, in… read more here.
Keywords: vivo safety; hht; pegylated liposomes; antileukemic homoharringtonine ... See more keywords
Preclinical In Vivo Safety of Poly-Phosphorylated Superlubrication Vectors for the Treatment of Osteoarthritis
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DOI: 10.1177/01926233221105393
Abstract: Osteoarthritis (OA) can lead to a significant functional disability. Poly[2-(methacryloyloxy)ethyl phosphorylcholine] (pMPC) liposomes are a novel treatment modality for OA, intended to restore the natural lubrication properties of articular cartilage. Here, we report on two… read more here.
Keywords: safety; safety poly; preclinical vivo; poly ... See more keywords