VITAS, a sensitive in vivo selection assay to discover enzymes producing antiviral natural products.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc00638g
Abstract: To discover new broad-spectrum antiviral nucleotide analogues from natural resources or through protein engineering, we have developed a sensitive in vivo selection assay named Viral polymerase-Inhibition Toxin-Associated Selection (VITAS). We show that the assay works… read more here.
Keywords: vivo selection; selection assay; vitas sensitive; sensitive vivo ... See more keywords
The In Vivo Selection Method in Breast Cancer Metastasis
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22041886
Abstract: Metastasis is a complex event in cancer progression and causes most deaths from cancer. Repeated transplantation of metastatic cancer cells derived from transplanted murine organs can be used to select the population of highly metastatic… read more here.
Keywords: cancer; vivo selection; selection method; metastasis ... See more keywords