Ellagic acid as a potent anti-cancer drug: A comprehensive review on in vitro, in vivo, in silico and drug delivery studies.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2288
Abstract: Ellagic acid as a polyphenol or micronutrient which can be naturally found in different vegetables and fruits, have gained considerable attention for cancer therapy due to considerable biological activities and different molecular targets. Ellagic acid… read more here.
Keywords: cancer; vitro vivo; drug; delivery ... See more keywords
Synthesis, in vivo and in silico evaluation of novel 2,3‐dihydroquinazolin‐4(1H)‐one derivatives as potential anticonvulsant agents
Sign Up to like & getrecommendations! Published in 2019 at "Drug Development Research"
DOI: 10.1002/ddr.21506
Abstract: In light of the pharmacophoric structural requirements for achieving anticonvulsant activity, a series of N‐(1‐methyl‐4‐oxo‐2‐un/substituted‐1,2‐dihydroquinazolin‐3[4H]‐yl)benzamide (4a‐g) and N‐(1‐methyl‐4‐oxo‐2‐un/substituted‐1,2‐dihydroquinazolin‐3[4H]‐yl)‐2‐phenylacetamide (4h‐n) derivatives were synthesized in two steps starting from the reaction of N‐methyl isatoic anhydride with the… read more here.
Keywords: vivo silico; synthesis vivo; evaluation novel; dihydroquinazolin one ... See more keywords
In vivo and in silico screening for antimicrobial compounds from cyanobacteria
Sign Up to like & getrecommendations! Published in 2022 at "MicrobiologyOpen"
DOI: 10.1002/mbo3.1268
Abstract: Due to the emerging rise of multi‐drug resistant bacteria, the discovery of novel antibiotics is of high scientific interest. Through their high chemodiversity of bioactive secondary metabolites, cyanobacteria have proven to be promising microorganisms for… read more here.
Keywords: silico screening; silico; vivo silico; screening antimicrobial ... See more keywords
Design, Synthesis, In Vivo, and In Silico Evaluation of Benzothiazoles Bearing a 1,3,4-Oxadiazole Moiety as New Antiepileptic Agents
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c06967
Abstract: In the presented manuscript, a new series of 2-[4-methoxy-3-(5-substituted phenyl-[1,3,4]oxadiazol-2-ylmethoxy)-phenyl]-benzothiazoles (6a–n) have been synthesized and studied in vivo and in silico for their anticonvulsant potential. Maximum electroshocks (MES) and subcutaneous pentylenetetrazol (scPTZ) models have been… read more here.
Keywords: design synthesis; silico; silico studies; vivo silico ... See more keywords
Hypoglycemic and hepatoprotective effects in adult zebrafish (Danio rerio) of fisetinidol isolated from Bauhinia pentandra: In vivo and in silico assays
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2029771
Abstract: Abstract Diabetes mellitus is a chronic metabolic disorder that has been increasing drastically around the worldwide. It is important to emphasize that although many drugs are commercially available to treat diabetes, many of them have… read more here.
Keywords: hypoglycemic hepatoprotective; vivo silico; adult zebrafish; fisetinidol ... See more keywords
New insights on the phytochemical intervention for the treatment of neuropsychiatric disorders using the leaves of Michelia champaca: an in vivo and in silico approach
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2022.2101669
Abstract: Abstract Context Michelia champaca L. (Magnoliaceae) has been known since ancient times for its rich medicinal properties. Objective The ethanol extract of Michelia champaca leaves (EEMC) was evaluated on depression and anxiety using in vivo… read more here.
Keywords: silico; vivo silico; silico studies; activity ... See more keywords
In vivo and in silico evaluation of the ameliorative effect of hesperidin on finasteride-induced testicular oxidative stress in Wistar rats
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology Mechanisms and Methods"
DOI: 10.1080/15376516.2020.1831123
Abstract: Abstract Finasteride used for treating benign prostatic hyperplasia is associated with undesirable side effects via oxidative stress related mechanisms. This study employed in vivo and in silico methods to investigate the protective role of hesperidin… read more here.
Keywords: vivo silico; finasteride; hesperidin; wistar rats ... See more keywords
In vivo and in silico dynamics of the development of Metabolic Syndrome
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DOI: 10.1371/journal.pcbi.1006145
Abstract: The Metabolic Syndrome (MetS) is a complex, multifactorial disorder that develops slowly over time presenting itself with large differences among MetS patients. We applied a systems biology approach to describe and predict the onset and… read more here.
Keywords: vivo silico; model; biology; metabolic syndrome ... See more keywords
Antidiarrheal Potential of Viola canescens: In Vivo and In Silico Approaches
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DOI: 10.3390/ph16040489
Abstract: Viola canescens Wall. is an important medicinal plant with reported therapeutic benefits. The current work sought to investigate the antidiarrheal properties of V. canescens extracts both in vivo and in silico. This study applied molecular… read more here.
Keywords: antidiarrheal potential; viola canescens; vivo silico; diarrhea ... See more keywords
Annona cherimola Miller and Its Flavonoids, an Important Source of Products for the Treatment of Diabetes Mellitus: In Vivo and In Silico Evaluations
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16050724
Abstract: The antihyperglycemic activity of ethanolic extract from Annona cherimola Miller (EEAch) and its products were evaluated using in vivo and in silico assays. An α-glucosidase inhibition was evaluated with oral sucrose tolerance tests (OSTT) and… read more here.
Keywords: molecular docking; vivo silico; cherimola miller; annona cherimola ... See more keywords
The LC-MS/MS Identification and Analgesic and Wound Healing Activities of Lavandula officinalis Chaix: In Vivo and In Silico Approaches
Sign Up to like & getrecommendations! Published in 2022 at "Plants"
DOI: 10.3390/plants11233222
Abstract: We earlier emphasized in vivo the lavender plant’s (Lavandula officinalis Chaix.) anti-inflammatory and estrogenic activities and described the chemical compositions of its hydro-ethanolic (HE) extract. We used LC-MS/MS and GC-MS analyses to profile the phytochemical… read more here.
Keywords: wound healing; vivo silico; analgesic wound; officinalis chaix ... See more keywords