A new ex vivo skin model for mechanistic understanding of putative anti-inflammatory topical therapeutics.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2022.121610
Abstract: Several in vitro models have been designed as test systems for inflammatory skin conditions, commonly using cell-culture or reconstructed human epidermis approaches. However, these systems poorly recapitulate the physiology and, importantly, the metabolism and biochemical… read more here.
Keywords: vivo skin; model mechanistic; skin model; model ... See more keywords
A new device for the combined measurement of friction and through-thickness deformation on ex vivo skin samples.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the mechanical behavior of biomedical materials"
DOI: 10.1016/j.jmbbm.2022.105141
Abstract: Skin irritation is a common phenomenon that becomes a real concern when caused by the use of medical devices. Because the materials used for the design of these devices are usually carefully selected for chemical… read more here.
Keywords: vivo skin; friction; new device; skin samples ... See more keywords
Monitoring UV‐induced signalling pathways in an ex vivo skin organ culture model using phospho‐antibody array
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Dermatology"
DOI: 10.1111/exd.13440
Abstract: We investigated UV‐induced signalling in an ex vivo skin organ culture model using phospho‐antibody array. Phosphorylation modulations were analysed in time‐course experiments following exposure to solar‐simulated UV and validated by Western blot analyses. We found… read more here.
Keywords: phospho antibody; vivo skin; skin organ; culture model ... See more keywords