In vivo toxicity of nitroaromatics: A comprehensive quantitative structure-activity relationship study.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.3761
Abstract: The toxicity data of 90 nitroaromatic compounds related to their 50% lethal dose concentration for rats (LD50) were analyzed to develop quantitative structure-activity relationship (QSAR) models. Quantum-chemically calculated descriptors together with molecular descriptors generated by… read more here.
Keywords: quantitative structure; toxicity; activity relationship; structure activity ... See more keywords
The Relationship between In Vivo Toxicity and Responsive pH in Transistor‐Like pH‐Sensitive Nanodetergents
Sign Up to like & getrecommendations! Published in 2024 at "Small Methods"
DOI: 10.1002/smtd.202401263
Abstract: Subacidity‐responsive materials (saRMs) have attracted considerable attention for disease‐specific pH‐responsive imaging and therapy. However, the guidance for their pH‐responsive design, aimed at achieving effective responses at lesion sites while minimizing unwanted responses in normal tissues,… read more here.
Keywords: transistor; normal tissues; toxicity; vivo toxicity ... See more keywords
Photocatalytic degradation of 3-methyl-4-nitrophenol over Ag/AgCl-decorated/[MOYI]-coated/ZnO nanostructures: Material characterization, photocatalytic performance, and in-vivo toxicity assessment of the photoproducts
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Technology and Innovation"
DOI: 10.1016/j.eti.2020.101212
Abstract: Abstract In this work, a facile ionic liquid-mediated method was utilized to fabricate an efficient photocatalyst for the environmental remediation. The eco-friendly aspect of the treatment was explored through an in-vivo toxicity bioassay. ZnO particles,… read more here.
Keywords: methyl; photocatalytic performance; toxicity; degradation methyl ... See more keywords
The synthesis of methotrexate-loaded F127 microemulsions and their in vivo toxicity in a rat model
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2020.113449
Abstract: Abstract Methotrexate (MTX) has been often formulated as nano and micro-emulsions, nominally to address its poor solubility and off-target effects. Nanoformulated MTX is universally reported to be a more efficacious anti-cancer agent than direct-dissolved drug;… read more here.
Keywords: methotrexate; drug; mtx; rat model ... See more keywords
ChemBioSim: Enhancing Conformal Prediction of In Vivo Toxicity by Use of Predicted Bioactivities
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.1c00451
Abstract: Computational methods such as machine learning approaches have a strong track record of success in predicting the outcomes of in vitro assays. In contrast, their ability to predict in vivo endpoints is more limited due… read more here.
Keywords: vivo endpoints; bioactivity; conformal prediction; vivo toxicity ... See more keywords
In vivo toxicity evaluation of nanoemulsions for drug delivery
Sign Up to like & getrecommendations! Published in 2019 at "Drug and Chemical Toxicology"
DOI: 10.1080/01480545.2019.1659806
Abstract: Abstract Lipid nanocarriers (LNs), for example nanoemulsions (NE), are an emerging tool for drug delivery due to their ability to incorporate drugs, protect the drug from degradation, improve bioavailability, and control release. Although LNs are… read more here.
Keywords: toxicity evaluation; drug delivery; delivery; drug ... See more keywords
Fullerenes in vivo. Toxicity and protective effects
Sign Up to like & getrecommendations! Published in 2025 at "Nanotoxicology"
DOI: 10.1080/17435390.2025.2471273
Abstract: Abstract The data available in the literature on the toxicity of fullerenes are numerous but contradictory. The ambiguity of research results hinders the transition from scientific research to real-world drug development. The ability of fullerenes… read more here.
Keywords: protective effects; administration; toxicity; fullerenes vivo ... See more keywords
Exploring the in vivo toxicity of nanoparticles
Sign Up to like & getrecommendations! Published in 2017 at "Canadian Journal of Chemistry"
DOI: 10.1139/cjc-2017-0203
Abstract: Toxicological tests of a xenobiotic play a key role to determine the safety of the new compound before it reaches the market. In this review article, we describe the main types of toxicological studies that… read more here.
Keywords: exploring vivo; toxicity nanoparticles; chemistry; vivo toxicity ... See more keywords
Using the concordance of in vitro and in vivo data to evaluate extrapolation assumptions
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0217564
Abstract: Linking in vitro bioactivity and in vivo toxicity on a dose basis enables the use of high-throughput in vitro assays as an alternative to traditional animal studies. In this study, we evaluated assumptions in the… read more here.
Keywords: bioactivity; vivo; vivo toxicity; vitro vivo ... See more keywords
The In Vivo Toxicity Assessments of Water-Dispersed Fluorescent Silicon Nanoparticles in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph19074101
Abstract: Fluorescent silicon nanoparticles (SiNPs), resembling a typical zero-dimensional silicon nanomaterial, have shown great potential in a wide range of biological and biomedical applications. However, information regarding the toxicity of this material in live organisms is… read more here.
Keywords: vivo toxicity; silicon nanoparticles; toxicity; caenorhabditis elegans ... See more keywords
pH Responsive Abelmoschus esculentus Mucilage and Administration of Methotrexate: In-Vitro Antitumor and In-Vivo Toxicity Evaluation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052725
Abstract: The rapid progression in biomaterial nanotechnology apprehends the potential of non-toxic and potent polysaccharide delivery modules to overcome oral chemotherapeutic challenges. The present study is aimed to design, fabricate and characterize polysaccharide nanoparticles for methotrexate… read more here.
Keywords: esculentus mucilage; vivo toxicity; abelmoschus esculentus; responsive abelmoschus ... See more keywords