Prediction of the Contribution Ratio of a Target Metabolic Enzyme to Clearance from Chemical Structure Information.
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DOI: 10.1021/acs.molpharmaceut.2c00698
Abstract: The contribution ratio of metabolic enzymes such as cytochrome P450 to in vivo clearance (fraction metabolized: fm) is a pharmacokinetic index that is particularly important for the quantitative evaluation of drug-drug interactions. Since obtaining experimental… read more here.
Keywords: information; structure information; vivo values; chemical structure ... See more keywords