GGCX mutants that impair hemostasis reveal the importance of processivity and full carboxylation to VKD protein function.
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DOI: 10.1182/blood.2021014275
Abstract: The gamma-glutamyl carboxylase (GGCX) generates multiple carboxylated Glus (Glas) in vitamin K-dependent (VKD) proteins that are required for their functions. GGCX is processive, remaining bound to VKD proteins throughout the multiple Glu carboxylations, and this… read more here.
Keywords: vkd protein; vkd; carboxylation; processivity ... See more keywords