Dosing algorithms for vitamin K antagonists across VKORC1 and CYP2C9 genotypes
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.13615
Abstract: Essentials Prospective studies of pharmacogenetic‐guided (PG) coumarin dosing produced varying results. EU‐PACT acenocoumarol and phenprocoumon trials compared PG and non‐PG dosing algorithms. Sub‐analysis of EU‐PACT identified differences between trial arms across VKORC1‐CYP2C9 groups. Adjustment of… read more here.
Keywords: dosing algorithms; vkorc1 cyp2c9; algorithms vitamin; across vkorc1 ... See more keywords
Determination of Pleiotropic Effect of Warfarin in VKORC1 and CYP2C9 Genotypes in Patients With Heart Valve Replacement
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.895169
Abstract: Warfarin has been widely used as an oral anticoagulant agent. In past, efforts have been done to study the contribution of genetic variation on warfarin dose requirements. The possible therapeutic dose determination of warfarin is… read more here.
Keywords: valve replacement; cyp2c9; vkorc1 cyp2c9; patients heart ... See more keywords