Methods for Investigating VLA-4 (CD49d/CD29) Expression and Activation in Chronic Lymphocytic Leukemia and Its Clinical Applications.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8876-1_8
Abstract: The integrin heterodimer CD49d/CD29 (a.k.a. Very Late Antigen-4, VLA-4) mediates cell-cell and cell-matrix interaction through the binding of its ligands VCAM-1 and fibronectin. VLA-4 can be present on the cell surface at different conformation states… read more here.
Keywords: vla; lymphocytic leukemia; cd49d; expression ... See more keywords
Importance and difficulty with valued life activities for people with systemic sclerosis
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DOI: 10.1080/09638288.2022.2028910
Abstract: Abstract Purpose To identify the importance of and difficulty with valued activities in persons with systemic sclerosis (SSc) and to examine relationships between disease symptoms and difficulty with valued activities using the Valued Activities Scale… read more here.
Keywords: importance difficulty; people ssc; systemic sclerosis; vla ... See more keywords
Revisiting the Dragonfly galaxy I. High-resolution ALMA and VLA observations of the radio hotspots in a hyper-luminous infrared galaxy at z = 1.92
Sign Up to like & getrecommendations! Published in 2023 at "Monthly Notices of the Royal Astronomical Society"
DOI: 10.1093/mnras/stad1428
Abstract: Radio-loud active galactic nuclei (RLAGNs) are rare among AGN populations. Lacking high-resolution and high-frequency observations, their structure and evolution stages are not well understood at high redshifts. In this work, we report ALMA 237 GHz continuum… read more here.
Keywords: galaxy; vla; high resolution; resolution ... See more keywords
ALMA and VLA observations of the HD 141569 system
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DOI: 10.1093/mnras/stx3098
Abstract: We present VLA 9 mm (33 GHz) observations of the HD 141569 system from semester 16A. The observations achieve a resolution of 0.25 arcsec ($\sim28$ au) and a sensitivity of $4.7~\mu \rm Jy~beam^{-1}$. We find… read more here.
Keywords: observations 141569; vla; vla observations; 141569 system ... See more keywords
Cygnus A super-resolved via convex optimization from VLA data
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DOI: 10.1093/mnras/sty372
Abstract: We leverage the Sparsity Averaging Reweighted Analysis (SARA) approach for interferometric imaging, that is based on convex optimisation, for the super-resolution of Cyg A from observations at the frequencies 8.422GHz and 6.678GHz with the Karl… read more here.
Keywords: vla; convex optimization; super resolved; via convex ... See more keywords
Low molecular weight heparin inhibits sickle erythrocyte adhesion to VCAM‐1 through VLA‐4 blockade in a standardized microfluidic flow adhesion assay
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DOI: 10.1111/bjh.14137
Abstract: Keywords: erythrocytes; adhesion; VLA-4; sickle cell disease; low molecular weight heparin read more here.
Keywords: low molecular; vla; adhesion; weight heparin ... See more keywords
The VLA-4 Integrin Is Constitutively Activated in a Fraction of CD49d-Expressing Chronic Lymphocytic Leukemia Via Autonomous BCR-Mediated Signaling
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DOI: 10.1182/blood-2019-124313
Abstract: Introduction. In chronic lymphocytic leukemia (CLL), CD49d, the alpha chain of the heterodimer CD49d/CD29 (VLA-4), is a strong negative prognosticator, and a key player of CLL microenvironmental interactions. The adhesive properties of VLA-4 can be… read more here.
Keywords: bcr; vla; constitutive vla; cd49d ... See more keywords
VLA-4 phosphorylation during tumor and immune cell migration relies on its coupling to VEGFR2 and CXCR4 by syndecan-1
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DOI: 10.1242/jcs.232645
Abstract: ABSTRACT When targeted by the tumor-promoting enzyme heparanase, cleaved and shed syndecan-1 (Sdc1) then couples VEGFR2 (also known as KDR) to VLA-4, activating VEGFR2 and the directed migration of myeloma cells. But how VEGFR2 activates… read more here.
Keywords: vla; migration; cell; phosphorylation ... See more keywords