Thioesterase Superfamily Member 2 Promotes Hepatic VLDL Secretion by Channeling Fatty Acids Into Triglyceride Biosynthesis
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30411
Abstract: In nonalcoholic fatty liver disease (NAFLD), triglycerides accumulate within the liver because the rates of fatty acid accrual by uptake from plasma and de novo synthesis exceed elimination by mitochondrial oxidation and secretion as very… read more here.
Keywords: vldl secretion; fatty acids; them2; superfamily member ... See more keywords
Leptin increases hepatic triglyceride export via a vagal mechanism in humans.
Sign Up to like & getrecommendations! Published in 2022 at "Cell metabolism"
DOI: 10.2139/ssrn.4078237
Abstract: Recombinant human leptin (metreleptin) reduces hepatic lipid content in patients with lipodystrophy and overweight patients with non-alcoholic fatty liver disease and relative hypoleptinemia independent of its anorexic action. In rodents, leptin signaling in the brain… read more here.
Keywords: mechanism; hepatic lipid; lipid content; export via ... See more keywords
Long Noncoding RNA lncRHL Regulates Hepatic VLDL Secretion by Modulating hnRNPU/BMAL1/MTTP Axis
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DOI: 10.2337/db21-1145
Abstract: Dysregulation of hepatic VLDL secretion contributes to the pathogenesis of metabolic diseases, such as nonalcoholic fatty liver disease (NAFLD) and hyperlipidemia. Accumulating evidence has suggested that long noncoding RNAs (lncRNAs) had malfunctioning roles in the… read more here.
Keywords: secretion; bmal1; hepatic vldl; vldl secretion ... See more keywords