Production of a high purity, C‐tagged hepatitis B surface antigen fusion protein VLP vaccine for malaria expressed in Pichia pastoris under cGMP conditions
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28181
Abstract: Virus‐like particles (VLPs) induce strong humoral and cellular responses and have formed the basis of some currently licensed vaccines. Here, we present the method used for the production of R21, a VLP‐based anti‐sporozoite malaria vaccine,… read more here.
Keywords: clinical trials; cgmp; high purity; production ... See more keywords
Formalin treatment increases the stability and immunogenicity of coxsackievirus B1 VLP vaccine.
Sign Up to like & getrecommendations! Published in 2019 at "Antiviral research"
DOI: 10.1016/j.antiviral.2019.104595
Abstract: Type B Coxsackieviruses (CVBs) are a common cause of acute and chronic myocarditis, dilated cardiomyopathy and aseptic meningitis. However, no CVB-vaccines are available for human use. We have previously produced virus-like particles (VLPs) for CVB3… read more here.
Keywords: cvb1; treatment; stability immunogenicity; vaccine ... See more keywords
Identification of potent epitopes on hexon capsid protein and their evaluation as vaccine candidates against infections caused by members of Adenoviridae family.
Sign Up to like & getrecommendations! Published in 2021 at "Vaccine"
DOI: 10.1016/j.vaccine.2021.05.023
Abstract: Adenoviruses cause economically important diseases in vertebrates. Effective vaccines against adenoviral diseases are currently lacking. Here, we report a highly conserved epitopic region on hexon proteins of adenoviruses that generate a strong immune response when… read more here.
Keywords: protein; epitopic region; evaluation; vaccine ... See more keywords
Immunological responses following administration of a genotype 1a/1b/2/3a quadrivalent HCV VLP vaccine
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-24762-9
Abstract: The significant public health problem of Hepatitis C virus (HCV) has been partially addressed with the advent of directly acting antiviral agents (DAAs). However, the development of an effective preventative vaccine would have a significant… read more here.
Keywords: hcv vlp; hcv; vaccine; quadrivalent hcv ... See more keywords
Zika virus-like particle (VLP) based vaccine
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0005608
Abstract: The newly emerged mosquito-borne Zika virus poses a major public challenge due to its ability to cause significant birth defects and neurological disorders. The impact of sexual transmission is unclear but raises further concerns about… read more here.
Keywords: like particle; vaccine; virus like; zika virus ... See more keywords