Deletion of the vesicular monoamine transporter 1 (vmat1/slc18a1) gene affects dopamine signaling
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research"
DOI: 10.1016/j.brainres.2019.01.029
Abstract: The vesicular monoamine transporter is involved in presynaptic catecholamine storage and neurotransmission. Two isoforms of the transporter exist, VMAT1 and VMAT2, and both are expressed in the brain, though VMAT2 expression is more robust and… read more here.
Keywords: monoamine transporter; vesicular monoamine; expression; vmat1 ... See more keywords
Association study of the vesicular monoamine transporter 1 (VMAT1) gene with autism in an Iranian population.
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DOI: 10.1016/j.gene.2017.05.003
Abstract: Autism Spectrum Disorders (ASD) (MIM 209850) are a group of neurodevelopmental disorders distinguished by destructed social interaction and communication abilities along with peculiar repetitive behavior. Several genetic loci have been linked to this disorder. Vesicular… read more here.
Keywords: transporter vmat1; vesicular monoamine; vmat1; monoamine transporter ... See more keywords
Human-specific mutations in VMAT1 confer functional changes and multi-directional evolution in the regulation of monoamine circuits
Sign Up to like & getrecommendations! Published in 2019 at "BMC Evolutionary Biology"
DOI: 10.1186/s12862-019-1543-8
Abstract: BackgroundNeurochemicals like serotonin and dopamine play crucial roles in human cognitive and emotional functions. Vesicular monoamine transporter 1 (VMAT1) transports monoamine neurotransmitters, and its variant (136Thr) is associated with various psychopathological symptoms and reduced monoamine… read more here.
Keywords: evolution; monoamine uptake; functional changes; vmat1 ... See more keywords