Ventromedial hypothalamus glucose‐inhibited neurones: A role in glucose and energy homeostasis?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.12773
Abstract: The ventromedial hypothalamus (VMH) plays a complex role in glucose and energy homeostasis. The VMH is necessary for the counter‐regulatory response to hypoglycaemia (CRR) that increases hepatic gluconeogenesis to restore euglycaemia. On the other hand,… read more here.
Keywords: vmh; energy; energy homeostasis; role ... See more keywords
In vivo photometry reveals insulin and 2-deoxyglucose maintain prolonged inhibition of VMH Vglut2 neurons in male mice.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1210/endocr/bqac095
Abstract: The ventromedial hypothalamic nucleus (VMH) is a well-established hub for energy and glucose homeostasis. In particular, VMH neurons are thought to be important for initiating the counter-regulatory response to hypoglycaemia, and ex vivo electrophysiology and… read more here.
Keywords: vglut2 neurons; vmh vglut2; response; insulin deoxyglucose ... See more keywords
Systemic Glucoregulation by Glucose-Sensing Neurons in the Ventromedial Hypothalamic Nucleus (VMH)
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2016-1104
Abstract: The ventromedial hypothalamic nucleus (VMH) regulates glucose production in the liver as well as glucose uptake and utilization in peripheral tissues, including skeletal muscle and brown adipose tissue, via efferent sympathetic innervation and neuroendocrine mechanisms.… read more here.
Keywords: vmh; glucose sensing; ventromedial hypothalamic; nucleus vmh ... See more keywords
Astrocyte glycogen is a major source of hypothalamic lactate in rats with recurrent hypoglycemia.
Sign Up to like & getrecommendations! Published in 2023 at "Diabetes"
DOI: 10.2337/db22-0902
Abstract: Lactate is an important metabolic substrate for sustaining brain energy requirements when glucose supplies are limited. Recurring exposure to hypoglycemia (RH) raises lactate levels in the ventromedial hypothalamus (VMH) which contributes to counter-regulatory failure. However,… read more here.
Keywords: major source; lactate; hypoglycemia; vmh ... See more keywords
Regulation of Satiety by Bdnf-e2-Expressing Neurons through TrkB Activation in Ventromedial Hypothalamus
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13050822
Abstract: The transcripts for Bdnf (brain-derived neurotrophic factor), driven by different promoters, are expressed in different brain regions to control different body functions. Specific promoter(s) that regulates energy balance remain unclear. We show that disruption of… read more here.
Keywords: satiety; vmh; ventromedial hypothalamus; bdnf ... See more keywords