Ketamine increases vmPFC activity: Effects of (R)- and (S)-stereoisomers and (2R,6R)-hydroxynorketamine metabolite
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DOI: 10.1016/j.neuropharm.2020.107947
Abstract: Ketamine, an NMDA receptor antagonist and fast acting antidepressant, produces a rapid burst of glutamate in the ventral medial prefrontal cortex (mPFC). Preclinical studies have demonstrated that pyramidal cell activity in the vmPFC is necessary… read more here.
Keywords: gcamp6f; nmda receptor; ketamine; effects ketamine ... See more keywords