The influence of antibody humanization on shark variable domain (VNAR) binding site ensembles
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DOI: 10.3389/fimmu.2022.953917
Abstract: Sharks and other cartilaginous fish produce new antigen receptor (IgNAR) antibodies, as key part of their humoral immune response and are the phylogenetically oldest living organisms that possess an immunoglobulin (Ig)-based adaptive immune system. IgNAR… read more here.
Keywords: binding site; antibody humanization; vnar; humanization ... See more keywords
Identification of Anti-TNFα VNAR Single Domain Antibodies from Whitespotted Bambooshark (Chiloscyllium plagiosum)
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DOI: 10.3390/md20050307
Abstract: Tumor necrosis factor α (TNFα), an important clinical testing factor and drug target, can trigger serious autoimmune diseases and inflammation. Thus, the TNFα antibodies have great potential application in diagnostics and therapy fields. The variable… read more here.
Keywords: anti tnf; tnf; vnar; identification anti ... See more keywords