Screening and Interaction Analysis of Shark-Derived Nanobodies against Crayfish Major Allergen Pro c 2.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.5c01559
Abstract: Pro c 2 (arginine kinase) is a major allergen in crayfish (Procambarus clarkii). Shark-derived variable domains of new antigen receptors (VNARs) have advantages in developing allergen detection and immunotherapy. This study constructed a VNAR domain… read more here.
Keywords: vnar; vnar vnar; shark derived; major allergen ... See more keywords
The influence of antibody humanization on shark variable domain (VNAR) binding site ensembles
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.953917
Abstract: Sharks and other cartilaginous fish produce new antigen receptor (IgNAR) antibodies, as key part of their humoral immune response and are the phylogenetically oldest living organisms that possess an immunoglobulin (Ig)-based adaptive immune system. IgNAR… read more here.
Keywords: binding site; antibody humanization; vnar; humanization ... See more keywords
Isolation and Characterization of the First Antigen-Specific EGFRvIII vNAR from Freshwater Stingray (Potamotrygon spp.) as a Drug Carrier in Glioblastoma Cancer Cells
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DOI: 10.3390/ijms26030876
Abstract: Glioblastoma is the most common and highly malignant brain tumor in adults. New targeted therapeutic approaches are imperative. EGFRvIII has appealing therapeutic targets using monoclonal antibodies. Thus, endeavors toward developing new mAbs therapies for GBM… read more here.
Keywords: vnar; carrier; freshwater stingray; egfrviii vnar ... See more keywords
A Single-Domain VNAR Nanobody Binds with High-Affinity and Selectivity to the Heparin Pentasaccharide Fondaparinux
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DOI: 10.3390/ijms26094045
Abstract: Glycosaminoglycans (GAGs) are key ligands for proteins involved in physiological and pathological processes. Specific GAG-binding patterns are rarely identified, with the heparin pentasaccharide as an Antithrombin-III ligand being the best characterized. Generating glycan-specific antibodies is… read more here.
Keywords: high affinity; heparin pentasaccharide; vnar; fondaparinux ... See more keywords
Identification of Anti-TNFα VNAR Single Domain Antibodies from Whitespotted Bambooshark (Chiloscyllium plagiosum)
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DOI: 10.3390/md20050307
Abstract: Tumor necrosis factor α (TNFα), an important clinical testing factor and drug target, can trigger serious autoimmune diseases and inflammation. Thus, the TNFα antibodies have great potential application in diagnostics and therapy fields. The variable… read more here.
Keywords: anti tnf; tnf; vnar; identification anti ... See more keywords