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Voacanga globosa Spirobisindole Alkaloids Exert Antiviral Activity in HIV Latently Infected Cell Lines by Targeting the NF-kB Cascade: In Vitro and In Silico Investigations

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Published in 2022 at "Molecules"

DOI: 10.3390/molecules27031078

Abstract: Since the efficiency in the transcription of the HIV genome contributes to the success of viral replication and infectivity, we investigated the downregulating effects of the spirobisindole alkaloids globospiramine (1), deoxyvobtusine (2), and vobtusine lactone… read more here.

Keywords: hiv; activity; infected cell; cell lines ... See more keywords