Maternal exposure to volatile anesthetics induces IL-6 in fetal brains and affects neuronal development.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172682
Abstract: Most clinically used general anesthetics have demonstrated neurotoxicity in animal studies, but the related mechanisms remain unknown. Previous studies suggest that anesthetics affect neuronal development through neuroinflammation, and significant effects of neuroinflammation on neurogenesis and… read more here.
Keywords: neuronal development; volatile anesthetics; fetal brains; maternal exposure ... See more keywords
Effect of Volatile Anesthetics on Myocardial Infarction After Coronary Artery Surgery: A Post Hoc Analysis of a Randomized Trial.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cardiothoracic and vascular anesthesia"
DOI: 10.1053/j.jvca.2022.01.001
Abstract: OBJECTIVE To investigate the effect of volatile anesthetics on the rates of postoperative myocardial infarction (MI) and cardiac death after coronary artery bypass graft (CABG). DESIGN A post hoc analysis of a randomized trial. SETTING… read more here.
Keywords: group; myocardial infarction; analysis; tiva ... See more keywords
Lipid emulsion facilitates reversal from volatile anesthetics in a rodent model
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Toxicology"
DOI: 10.1080/15563650.2021.2020280
Abstract: Abstract Background Lipid emulsion infusion is a first-line therapy against the toxicity of local anesthetics and is a potential treatment for other drug overdoses, especially for highly lipophilic drugs. Considering the lipophilic property of volatile… read more here.
Keywords: emulsion infusion; lipid emulsion; sevoflurane; volatile anesthetics ... See more keywords
New Evidence of Receptor-based Pharmacology Underlying a Volatile Anesthetic Effect.
Sign Up to like & getrecommendations! Published in 2020 at "Anesthesiology"
DOI: 10.1097/aln.0000000000003559
Abstract: SINCE the 1980s, molecular hypotheses attributing general anesthesia to nonspecific membrane biophysical perturbations have largely receded, while researchers have embraced the idea that anesthetic drugs act directly at protein targets, that is, classical receptors. However,… read more here.
Keywords: potassium; volatile anesthetics; task; volatile anesthetic ... See more keywords
Brain DNA damaging effects of volatile anesthetics and 1 and 2 Gy gamma irradiation in vivo: Preliminary results
Sign Up to like & getrecommendations! Published in 2023 at "Toxicology and Industrial Health"
DOI: 10.1177/07482337221145599
Abstract: Although both can cause DNA damage, the combined impact of volatile anesthetics halothane/sevoflurane/isoflurane and radiotherapeutic exposure on sensitive brain cells in vivo has not been previously analyzed. Healthy Swiss albino male mice (240 in total,… read more here.
Keywords: tail intensity; dna; brain; isoflurane ... See more keywords
A primordial target: Mitochondria mediate both primary and collateral anesthetic effects of volatile anesthetics.
Sign Up to like & getrecommendations! Published in 2023 at "Experimental biology and medicine"
DOI: 10.1177/15353702231165025
Abstract: One of the unsolved mysteries of medicine is how do volatile anesthetics (VAs) cause a patient to reversibly lose consciousness. In addition, identifying mechanisms for the collateral effects of VAs, including anesthetic-induced neurotoxicity (AiN) and… read more here.
Keywords: primary collateral; primordial target; medicine; target mitochondria ... See more keywords
Risk factors for postoperative nausea and vomiting after the removal of impacted third molars: a cross-sectional study
Sign Up to like & getrecommendations! Published in 2021 at "BMC Oral Health"
DOI: 10.1186/s12903-021-01481-8
Abstract: Background A better understanding of the risk factors for postoperative nausea and vomiting (PONV) could improve patient outcomes. This study aimed to analyze the risk factors for PONV and its onset after third molar impaction… read more here.
Keywords: risk; volatile anesthetics; factors postoperative; risk factors ... See more keywords
Volatile anesthetics versus total intravenous anesthesia in patients undergoing coronary artery bypass grafting: An updated meta-analysis and trial sequential analysis of randomized controlled trials
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0224562
Abstract: Background The benefits of volatile anesthetics in coronary artery bypass grafting (CABG) patients remain controversial. We aimed to conduct an updated meta-analysis to assess whether the use of volatile anesthetics during CABG could reduce mortality… read more here.
Keywords: volatile anesthetics; analysis; artery bypass; coronary artery ... See more keywords
Volatile Anesthetics Regulate Anti-Cancer Relevant Signaling
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.610514
Abstract: Volatile anesthetics are widely used inhalation anesthetics in clinical anesthesia. In recent years, the regulation of anti-cancer relevant signaling of volatile anesthetics has drawn the attention of investigators. However, their underlying mechanism remains unclear. This… read more here.
Keywords: relevant signaling; volatile anesthetics; cancer relevant; signaling volatile ... See more keywords
Mechanisms underlying neonate-specific metabolic effects of volatile anesthetics
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.65400
Abstract: Volatile anesthetics (VAs) are widely used in medicine, but the mechanisms underlying their effects remain ill-defined. Though routine anesthesia is safe in healthy individuals, instances of sensitivity are well documented, and there has been significant… read more here.
Keywords: underlying neonate; volatile anesthetics; neonate specific; mechanisms underlying ... See more keywords