Integrative Approach with Electrophysiological and Theoretical Methods Reveals a New Role of S4 Positively Charged Residues in PKD2L1 Channel Voltage-Sensing
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10357-3
Abstract: Numerical model-based simulations provide important insights into ion channel gating when experimental limitations exist. Here, a novel strategy combining numerical simulations with patch clamp experiments was used to investigate the net positive charges in the… read more here.
Keywords: voltage; approach electrophysiological; integrative approach; pkd2l1 channel ... See more keywords
Investigation on the Voltage Dependence of Compressed-Gas-Insulated Capacitors up to 400 kV by Improved Voltage-Doubling Method
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Transactions on Instrumentation and Measurement"
DOI: 10.1109/tim.2022.3210954
Abstract: This article presents a recent improvement in the measurement of voltage dependence of compressed gas capacitors up to 400 kV using the voltage-doubling method. Two identical 10-nF high-voltage capacitors in series are employed to generate… read more here.
Keywords: voltage doubling; voltage; compressed gas; voltage dependence ... See more keywords
Human KCNQ5 de novo Mutations Underlie Epilepsy and Intellectual Disability.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neurophysiology"
DOI: 10.1152/jn.00509.2021
Abstract: We identified six novel de novo human KCNQ5 variants in children with motor/language delay, intellectual disability (ID) and/or epilepsy by whole-exome sequencing. These variants comprised of two nonsense and four missense alterations, were functionally characterized… read more here.
Keywords: intellectual disability; gof; human kcnq5; kcnq5 ... See more keywords
Voltage dependence of the cannabinoid CB1 receptor
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1022275
Abstract: Cannabinoids produce their characteristic effects mainly by binding to two types of G-protein coupled receptors (GPCRs), the CB1 and CB2 cannabinoid receptors. The CB1 receptor is the main cannabinoid receptor in the central nervous system,… read more here.
Keywords: cannabinoid; cb1 receptor; voltage dependence; receptor voltage ... See more keywords
Triplin: Functional Probing of Its Structure and the Dynamics of the Voltage-Gating Process
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232213765
Abstract: Gram-negative bacteria have a large variety of channel-forming proteins in their outer membrane, generally referred to as porins. Some display weak voltage dependence. A similar trimeric channel former, named Triplin, displays very steep voltage dependence,… read more here.
Keywords: triplin functional; voltage; functional probing; voltage gating ... See more keywords