The asparagine 533 residue in the outer pore loop region of the mouse PKD2L1 channel is essential for its voltage‐dependent inactivation
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12273
Abstract: Voltage‐dependent inactivation of ion channels contributes to the regulation of the membrane potential of excitable cells. Mouse polycystic kidney disease 2‐like 1 (PKD2L1) forms voltage‐dependent nonselective cation channels, which are activated but subsequently inactivated in… read more here.
Keywords: pore loop; pkd2l1; outer pore; inactivation ... See more keywords
Synergistic antinociception between ZC88, an N‐type voltage‐dependent calcium channel blocker, and ibuprofen in mouse models of visceral and somatic inflammatory pain
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DOI: 10.1002/ejp.1281
Abstract: A combination of analgesic agents with different mechanisms can induce additive or synergistic analgesia. The N‐type voltage‐dependent calcium channel (N‐VDCC) is a novel therapeutic target for pain control. In addition to providing effective pain relief… read more here.
Keywords: type voltage; calcium channel; dependent calcium; voltage dependent ... See more keywords
Voltage‐dependent activation of Rac1 by Nav1.5 channels promotes cell migration
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DOI: 10.1002/jcp.29290
Abstract: Ion channels can regulate the plasma membrane potential (Vm) and cell migration as a result of altered ion flux. However, the mechanism by which Vm regulates motility remains unclear. Here, we show that the Nav1.5… read more here.
Keywords: rac1 activation; cell migration; migration; voltage dependent ... See more keywords
Targeting microglia L‐type voltage‐dependent calcium channels for the treatment of central nervous system disorders
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DOI: 10.1002/jnr.24585
Abstract: Calcium (Ca2+) is a ubiquitous mediator of a multitude of cellular functions in the central nervous system (CNS). Intracellular Ca2+ is tightly regulated by cells, including entry via plasma membrane Ca2+ permeable channels. Of specific… read more here.
Keywords: type voltage; nervous system; central nervous; treatment ... See more keywords
Inhibitory Effect of Tricyclic Antidepressant Doxepin on Voltage-Dependent K+ Channels in Rabbit Coronary Arterial Smooth Muscle Cells
Sign Up to like & getrecommendations! Published in 2019 at "Cardiovascular Toxicology"
DOI: 10.1007/s12012-019-09519-8
Abstract: Doxepin, tricyclic antidepressant, is widely used for the treatment of depressive disorders. Our present study determined the inhibitory effect of doxepin on voltage-dependent K+ (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells… read more here.
Keywords: doxepin; tricyclic antidepressant; voltage dependent; inhibitory effect ... See more keywords
Ph-Induced Oligomerization of the Voltage Dependent Anion Channel
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DOI: 10.1016/j.bpj.2016.11.1018
Abstract: The Voltage-Dependent Anion Channel (VDAC) is the most abundant protein in the outer mitochondrial membrane facilitating the passage of ions and metabolites between the cytoplasm and the intermembrane space. In addition to its critical role… read more here.
Keywords: dependent anion; anion channel; microscopy; induced oligomerization ... See more keywords
Optically Probing the Mechanism of Voltage-Dependent Facilitation in CaV1.2 Channels
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DOI: 10.1016/j.bpj.2016.11.1337
Abstract: An important regulatory mechanism of excitation-evoked Ca2+ influx is voltage-dependent, or pre-pulse, facilitation (VDF): a memory property of some CaV channels, whereby channel activation is enhanced following a pre-conditioning pulse of sufficient duration and amplitude.… read more here.
Keywords: voltage; mechanism; facilitation; voltage dependent ... See more keywords
Sparsification of AP firing in adult-born hippocampal granule cells via voltage-dependent α5-GABAA receptors.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109768
Abstract: GABA can depolarize immature neurons close to the action potential (AP) threshold in development and adult neurogenesis. Nevertheless, GABAergic synapses effectively inhibit AP firing in newborn granule cells of the adult hippocampus as early as… read more here.
Keywords: adult; hippocampal granule; voltage dependent; gabaa receptors ... See more keywords
Inhibition of voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells by the class Ic antiarrhythmic agent lorcainide.
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DOI: 10.1016/j.ejphar.2021.174158
Abstract: Voltage-dependent K+ (Kv) channels play the role of returning the membrane potential to the resting state, thereby maintaining the vascular tone. Here, we used native smooth-muscle cells from rabbit coronary arteries to investigate the inhibitory… read more here.
Keywords: voltage; inhibition; muscle cells; voltage dependent ... See more keywords
The N-Terminal Segment of the Voltage-Dependent Anion Channel: A Possible Membrane-Bound Intermediate in Pore Unbinding.
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DOI: 10.1016/j.jmb.2018.09.015
Abstract: The voltage-dependent anion channel (VDAC) resides in the outer mitochondrial membrane and can adopt a closed or open configuration, most likely depending on whether the N-terminal segment (NTS) occupies the pore or protrudes into the… read more here.
Keywords: dependent anion; membrane bound; anion channel; voltage dependent ... See more keywords
Differential Control of Axonal and Somatic Resting Potential by Voltage-Dependent Conductances in Cortical Layer 5 Pyramidal Neurons
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DOI: 10.1016/j.neuron.2018.02.016
Abstract: Voltage-dependent conductances not only drive action potentials but also help regulate neuronal resting potential. We found differential regulation of resting potential in the proximal axon of layer 5 pyramidal neurons compared to the soma. Axonal… read more here.
Keywords: resting potential; control; dependent conductances; layer pyramidal ... See more keywords