Voltage‐gated sodium channels β3 subunit promotes tumorigenesis in hepatocellular carcinoma by facilitating p53 degradation
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13641
Abstract: The voltage‐gated sodium channels (VGSCs) are aberrantly expressed in a variety of tumors and play an important role in tumor growth and metastasis. Here, we show that VGSCs auxiliary β3 subunit, encoded by the SCN3B… read more here.
Keywords: degradation; p53 degradation; p53; gated sodium ... See more keywords
A Non‐Invasive and DNA‐free Approach to Upregulate Mammalian Voltage‐Gated Calcium Channels and Neuronal Calcium Signaling via Terahertz Stimulation (Adv. Sci. 47/2024)
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202470292
Abstract: Lighting the Channel This cover illustrates the activation of mammalian voltage‐gated calcium channels via terahertz waves, which resonate with the stretch mode of carboxyl groups in the selectivity filter. This DNA‐free, noninvasive method offers a… read more here.
Keywords: via terahertz; mammalian voltage; calcium; voltage gated ... See more keywords
Synthesis and Evaluation of Voltage‐Gated Sodium Channel Blocking Pyrroline Derivatives Endowed with Both Antiarrhythmic and Antioxidant Activities
Sign Up to like & getrecommendations! Published in 2020 at "ChemMedChem"
DOI: 10.1002/cmdc.202000692
Abstract: Under the hypothesis that cardioprotective agents might benefit from synergism between antiarrhythmic activity and antioxidant properties, a small series of mexiletine analogues were coupled with the 2,2,5,5‐tetramethylpyrroline moiety, known for its antioxidant effect, in order… read more here.
Keywords: sodium channel; pyrroline derivatives; synthesis evaluation; evaluation voltage ... See more keywords
Towards Multitargeted Ligands as Pain Therapeutics: Dual Ligands of the Cavα2δ‐1 Subunit of Voltage‐Gated Calcium Channel and the μ‐Opioid Receptor
Sign Up to like & getrecommendations! Published in 2024 at "ChemMedChem"
DOI: 10.1002/cmdc.202300473
Abstract: The synthesis and pharmacological activity of a new series of dual ligands combining activities towards the α2δ‐1 subunit of voltage‐gated calcium channels (Cavα2δ‐1) and the μ‐opioid receptor (MOR) as novel pain therapeutics are reported. A… read more here.
Keywords: pain therapeutics; voltage gated; opioid receptor; gated calcium ... See more keywords
The voltage‐gated calcium channel CaV1.2 promotes adult oligodendrocyte progenitor cell survival in the mouse corpus callosum but not motor cortex
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23723
Abstract: Throughout life, oligodendrocyte progenitor cells (OPCs) proliferate and differentiate into myelinating oligodendrocytes. OPCs express cell surface receptors and channels that allow them to detect and respond to neuronal activity, including voltage‐gated calcium channel (VGCC)s. The… read more here.
Keywords: channel; gated calcium; cav1; cell ... See more keywords
Extracellular S100B inhibits A‐type voltage‐gated potassium currents and increases L‐type voltage‐gated calcium channel activity in dopaminergic neurons
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24254
Abstract: Parkinson's disease (PD) is associated with an increase in secreted S100B within the midbrain and cerebrospinal fluid. In addition, S100B overexpression in mice accelerates the loss of substantia nigra pars compacta dopaminergic (DA) neurons, suggesting… read more here.
Keywords: type voltage; gated potassium; extracellular s100b; voltage gated ... See more keywords
Machine learning‐based approach for prediction of ion channels and their subclasses
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30343
Abstract: Ion channels are ion‐permeable protein pores that are found in all cell lipid membranes. Distinct ion channels play multiple roles in biological processes. Proteomic data is fast accumulating as a result of the fast growth… read more here.
Keywords: voltage gated; composition; subclasses voltage; ion channels ... See more keywords
Identification and Pharmacological Characterization of the Voltage-gated Potassium Channel Shab in Diamondback moth, Plutella xylostella.
Sign Up to like & getrecommendations! Published in 2022 at "Pest management science"
DOI: 10.1002/ps.7300
Abstract: BACKGROUND Voltage-gated potassium channel Kv2 is the primarily delayed rectifier in insect nerves and muscles involved in several crucial biological processes, including action potential regulation, photoreceptor performance, and larval locomotor. It is a potential molecular… read more here.
Keywords: gated potassium; voltage gated; plutella xylostella; potassium channel ... See more keywords
Point mutations in the voltage‐gated sodium channel gene conferring pyrethroid resistance in China populations of the Dermanyssus gallinae
Sign Up to like & getrecommendations! Published in 2024 at "Pest Management Science"
DOI: 10.1002/ps.8223
Abstract: Dermanyssus gallinae, the poultry red mite (PRM), is a worldwide ectoparasite posing significant economic challenges in poultry farming. The extensive use of pyrethroids for PRM control has led to the emergence of pyrethroid resistance. The… read more here.
Keywords: pyrethroid resistance; resistance; point mutations; mutations voltage ... See more keywords
Ganomycin C, a Ganoderma Meroterpenoid, Alleviates Pain and Absence Seizures in Mice by Targeting Cav3.1 and Cav3.2 Low‐Voltage‐Gated Calcium Channels
Sign Up to like & getrecommendations! Published in 2025 at "Phytotherapy Research"
DOI: 10.1002/ptr.8486
Abstract: Low‐voltage‐gated calcium channels (LVGCCs; Cav3.1–3.3) are promising targets for treating pain and absence seizures (ASs). Traditional Chinese medicines are potential sources of LVGCC inhibitors. In this study, we aimed to identify analgesic and anti‐ASs agents… read more here.
Keywords: ass; low voltage; voltage gated; gated calcium ... See more keywords
Voltage-Gated Nanoparticle Transport and Collisions in Attoliter-Volume Nanopore Electrode Arrays.
Sign Up to like & getrecommendations! Published in 2018 at "Small"
DOI: 10.1002/smll.201703248
Abstract: Single nanoparticle analysis can reveal how particle-to-particle heterogeneity affects ensemble properties derived from traditional bulk measurements. High-bandwidth, low noise electrochemical measurements are needed to examine the fast heterogeneous electron-transfer behavior of single nanoparticles with sufficient… read more here.
Keywords: voltage; voltage gated; attoliter volume; transport ... See more keywords