Voltage‐gated sodium channels β3 subunit promotes tumorigenesis in hepatocellular carcinoma by facilitating p53 degradation
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13641
Abstract: The voltage‐gated sodium channels (VGSCs) are aberrantly expressed in a variety of tumors and play an important role in tumor growth and metastasis. Here, we show that VGSCs auxiliary β3 subunit, encoded by the SCN3B… read more here.
Keywords: degradation; p53 degradation; p53; gated sodium ... See more keywords
Synthesis and Evaluation of Voltage‐Gated Sodium Channel Blocking Pyrroline Derivatives Endowed with Both Antiarrhythmic and Antioxidant Activities
Sign Up to like & getrecommendations! Published in 2020 at "ChemMedChem"
DOI: 10.1002/cmdc.202000692
Abstract: Under the hypothesis that cardioprotective agents might benefit from synergism between antiarrhythmic activity and antioxidant properties, a small series of mexiletine analogues were coupled with the 2,2,5,5‐tetramethylpyrroline moiety, known for its antioxidant effect, in order… read more here.
Keywords: sodium channel; pyrroline derivatives; synthesis evaluation; evaluation voltage ... See more keywords
The voltage‐gated calcium channel CaV1.2 promotes adult oligodendrocyte progenitor cell survival in the mouse corpus callosum but not motor cortex
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23723
Abstract: Throughout life, oligodendrocyte progenitor cells (OPCs) proliferate and differentiate into myelinating oligodendrocytes. OPCs express cell surface receptors and channels that allow them to detect and respond to neuronal activity, including voltage‐gated calcium channel (VGCC)s. The… read more here.
Keywords: channel; gated calcium; cav1; cell ... See more keywords
Extracellular S100B inhibits A‐type voltage‐gated potassium currents and increases L‐type voltage‐gated calcium channel activity in dopaminergic neurons
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24254
Abstract: Parkinson's disease (PD) is associated with an increase in secreted S100B within the midbrain and cerebrospinal fluid. In addition, S100B overexpression in mice accelerates the loss of substantia nigra pars compacta dopaminergic (DA) neurons, suggesting… read more here.
Keywords: type voltage; gated potassium; extracellular s100b; voltage gated ... See more keywords
Machine learning‐based approach for prediction of ion channels and their subclasses
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30343
Abstract: Ion channels are ion‐permeable protein pores that are found in all cell lipid membranes. Distinct ion channels play multiple roles in biological processes. Proteomic data is fast accumulating as a result of the fast growth… read more here.
Keywords: voltage gated; composition; subclasses voltage; ion channels ... See more keywords
Identification and Pharmacological Characterization of the Voltage-gated Potassium Channel Shab in Diamondback moth, Plutella xylostella.
Sign Up to like & getrecommendations! Published in 2022 at "Pest management science"
DOI: 10.1002/ps.7300
Abstract: BACKGROUND Voltage-gated potassium channel Kv2 is the primarily delayed rectifier in insect nerves and muscles involved in several crucial biological processes, including action potential regulation, photoreceptor performance, and larval locomotor. It is a potential molecular… read more here.
Keywords: gated potassium; voltage gated; plutella xylostella; potassium channel ... See more keywords
Voltage-Gated Nanoparticle Transport and Collisions in Attoliter-Volume Nanopore Electrode Arrays.
Sign Up to like & getrecommendations! Published in 2018 at "Small"
DOI: 10.1002/smll.201703248
Abstract: Single nanoparticle analysis can reveal how particle-to-particle heterogeneity affects ensemble properties derived from traditional bulk measurements. High-bandwidth, low noise electrochemical measurements are needed to examine the fast heterogeneous electron-transfer behavior of single nanoparticles with sufficient… read more here.
Keywords: voltage; voltage gated; attoliter volume; transport ... See more keywords
Toxins That Affect Voltage-Gated Sodium Channels.
Sign Up to like & getrecommendations! Published in 2018 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2017_66
Abstract: Voltage-gated sodium channels (VGSCs) are critical in generation and conduction of electrical signals in multiple excitable tissues. Natural toxins, produced by animal, plant, and microorganisms, target VGSCs through diverse strategies developed over millions of years… read more here.
Keywords: pharmacology; gated sodium; sodium channels; voltage gated ... See more keywords
Reduced cooperativity of voltage-gated sodium channels in the hippocampal interneurons of an aged mouse model of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2017 at "European Biophysics Journal"
DOI: 10.1007/s00249-017-1274-y
Abstract: Beta amyloid (A$$\beta$$β ) associated with Alzheimer’s disease (AD) leads to abnormal behavior in inhibitory neurons, resulting in hyperactive neuronal networks, epileptiform behavior, disrupted gamma rhythms, and aberrant synaptic plasticity. Previously, we used a dual… read more here.
Keywords: apde9 mice; alzheimer disease; ntg mice; mice ... See more keywords
[Pain and analgesia : Mutations of voltage-gated sodium channels].
Sign Up to like & getrecommendations! Published in 2017 at "Schmerz"
DOI: 10.1007/s00482-016-0139-0
Abstract: Voltage-gated sodium channels (Navs) are crucial for the generation and propagation of action potentials in all excitable cells, and therefore for the function of sensory neurons as well. Preclinical research over the past 20 years identified… read more here.
Keywords: function; gated sodium; sodium channels; pain ... See more keywords
Response of Voltage-Gated Sodium and Calcium Channels Subtypes on Dehydroepiandrosterone Treatment in Iron-Induced Epilepsy
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-020-00851-0
Abstract: Epilepsy is a neurological disorder characterized by the occurrence of spontaneous and recurrent seizures. In post-traumatic epilepsy (PTE), the mechanism of epileptogenesis is very complex and seems to be linked with voltage-gated ion channels. Dehydroepiandrosterone… read more here.
Keywords: channels subtypes; iron induced; induced epilepsy; voltage gated ... See more keywords