Voltage gating of mechanosensitive PIEZO channels
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03502-7
Abstract: Mechanosensitive PIEZO ion channels are evolutionarily conserved proteins whose presence is critical for normal physiology in multicellular organisms. Here we show that, in addition to mechanical stimuli, PIEZO channels are also powerfully modulated by voltage… read more here.
Keywords: voltage; piezo channels; mechanosensitive piezo; piezo ... See more keywords
Conformational rearrangements in the second voltage sensor domain switch PIP2- and voltage-gating modes in two-pore channels.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2209569120
Abstract: Two-pore channels (TPCs) are activated by phosphatidylinositol bisphosphate (PIP2) binding to domain I and/or by voltage sensing in domain II (DII). Little is known about how these two stimuli are integrated, and how each TPC… read more here.
Keywords: pore channels; voltage; domain; two pore ... See more keywords
Triplin: Functional Probing of Its Structure and the Dynamics of the Voltage-Gating Process
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DOI: 10.3390/ijms232213765
Abstract: Gram-negative bacteria have a large variety of channel-forming proteins in their outer membrane, generally referred to as porins. Some display weak voltage dependence. A similar trimeric channel former, named Triplin, displays very steep voltage dependence,… read more here.
Keywords: triplin functional; voltage; functional probing; voltage gating ... See more keywords