A scenario for the origin of life: Volume regulation by bacteriorhodopsin required extremely voltage sensitive Na‐channels and very selective K‐channels
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202100210
Abstract: The osmotic activity produced by internal, non‐permeable, anionic nucleic acids and metabolites causes a persistent and life‐threatening cell swelling, or cellular edema, produced by the Gibbs‐Donnan effect. This evolutionary‐critical osmotic challenge must have been resolved… read more here.
Keywords: voltage sensitive; sensitive channels; bacteriorhodopsin; volume ... See more keywords
Skeletal Functions of Voltage Sensitive Calcium Channels
Sign Up to like & getrecommendations! Published in 2021 at "Current Osteoporosis Reports"
DOI: 10.1007/s11914-020-00647-7
Abstract: Voltage-sensitive calcium channels (VSCCs) are ubiquitous multimeric protein complexes that are necessary for the regulation of numerous physiological processes. VSCCs regulate calcium influx and various intracellular processes including muscle contraction, neurotransmission, hormone secretion, and gene… read more here.
Keywords: sensitive calcium; calcium channels; functions vsccs; bone ... See more keywords
Chemical Targeting of Rhodol Voltage-Sensitive Dyes to Dopaminergic Neurons.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00862
Abstract: Optical imaging of changes in the membrane potential of living cells can be achieved by means of fluorescent voltage-sensitive dyes (VSDs). A particularly challenging task is to efficiently deliver these highly lipophilic probes to specific… read more here.
Keywords: brain tissue; voltage sensitive; voltage; chemical targeting ... See more keywords
Voltage-sensitive dye imaging of mouse neocortex during a whisker detection task
Sign Up to like & getrecommendations! Published in 2017 at "Neurophotonics"
DOI: 10.1117/1.nph.4.3.031204
Abstract: Abstract. Sensorimotor processing occurs in a highly distributed manner in the mammalian neocortex. The spatiotemporal dynamics of electrical activity in the dorsal mouse neocortex can be imaged using voltage-sensitive dyes (VSDs) with near-millisecond temporal resolution… read more here.
Keywords: whisker; voltage sensitive; spatiotemporal dynamics; sensorimotor ... See more keywords
Optical Spike Detection and Connectivity Analysis With a Far-Red Voltage-Sensitive Fluorophore Reveals Changes to Network Connectivity in Development and Disease
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.643859
Abstract: The ability to optically record dynamics of neuronal membrane potential promises to revolutionize our understanding of neurobiology. In this study, we show that the far-red voltage sensitive fluorophore, Berkeley Red Sensor of Transmembrane potential-1, or… read more here.
Keywords: voltage; red voltage; network; connectivity ... See more keywords
Gabapentin Disrupts Binding of Perlecan to the α2δ1 Voltage Sensitive Calcium Channel Subunit and Impairs Skeletal Mechanosensation
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12121857
Abstract: Our understanding of how osteocytes, the principal mechanosensors within bone, sense and perceive force remains unclear. Previous work identified “tethering elements” (TEs) spanning the pericellular space of osteocytes and transmitting mechanical information into biochemical signals.… read more here.
Keywords: voltage sensitive; bone; mechanosensation; gbp ... See more keywords