Palmitoylation of the pore-forming subunit of Ca(v)1.2 controls channel voltage sensitivity and calcium transients in cardiac myocytes
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2207887120
Abstract: Significance Proper functioning of the voltage-dependent Ca2+ channel Ca(v)1.2 is indispensable for the normal physiology of smooth, skeletal, and cardiac muscles and for that of neurons and endocrine cells. Here, we report that the pore-forming… read more here.
Keywords: pore forming; voltage sensitivity; forming subunit; voltage ... See more keywords
Intramolecular interactions that control voltage sensitivity in the jShak1 potassium channel from Polyorchis penicillatus
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DOI: 10.1242/jeb.144089
Abstract: ABSTRACT Voltage-gated potassium ion (Kv) channel proteins respond to changes in membrane potential by changing the probability of K+ flux through an ion-selective pore. Kv channels from different paralogous and orthologous families have widely varying… read more here.
Keywords: voltage; potassium channel; voltage sensitivity; polyorchis penicillatus ... See more keywords
Conserved Amino Acids Residing Outside the Voltage Field Can Shift the Voltage Sensitivity and Increase the Signal Speed and Size of Ciona Based GEVIs
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.868143
Abstract: To identify potential regions of the voltage-sensing domain that could shift the voltage sensitivity of Ciona intestinalis based Genetically Encoded Voltage Indicators (GEVIs), we aligned the amino acid sequences of voltage-gated sodium channels from different… read more here.
Keywords: amino acids; ciona; voltage sensing; voltage ... See more keywords