Models Used to Predict Chemical Bioaccumulation in Fish from in Vitro Biotransformation Rates Require Accurate Estimates of Blood–Water Partitioning and Chemical Volume of Distribution
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology and Chemistry"
DOI: 10.1002/etc.5503
Abstract: Methods for extrapolating measured in vitro intrinsic clearance to a whole‐body biotransformation rate constant (kB) have been developed to support modeled bioaccumulation assessments for fish. The inclusion of extrapolated kB values into existing bioaccumulation models… read more here.
Keywords: predict chemical; volume distribution; biotransformation; used predict ... See more keywords
Population Pharmacokinetics of Monalizumab in Patients with Advanced Solid Tumors.
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DOI: 10.1002/jcph.2220
Abstract: Monalizumab is a novel, first-in-class humanized immunoglobulin G (IgG)-4 monoclonal antibody (mAb) immune checkpoint inhibitor that targets the inhibitory CD94/NKG2A receptors. The objectives of this analysis were to develop a population pharmacokinetic (PK) model of… read more here.
Keywords: volume distribution; patients advanced; population pharmacokinetics; solid tumors ... See more keywords
The effect of neutropenia on the clinical pharmacokinetics of vancomycin in adults
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DOI: 10.1007/s00228-019-02657-6
Abstract: AimThere is accumulating evidence that neutropenic patients require higher dosages of vancomycin. To prevent sub-therapeutic drug exposure, it is of utmost importance to obtain adequate exposure from the first dose onwards. We aimed to quantify… read more here.
Keywords: effect neutropenia; volume distribution; patients known; pharmacokinetics vancomycin ... See more keywords
Population pharmacokinetics of NNZ‐2566 in healthy subjects
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DOI: 10.1016/j.ejps.2017.05.032
Abstract: Abstract NNZ‐2566 is a novel, small molecule being developed as a treatment for cognitive impairment in different CNS conditions, including Rett and Fragile‐X syndrome, both of which are associated with moderate to severe neurodevelopmental disorder.… read more here.
Keywords: volume distribution; pharmacokinetics nnz; population pharmacokinetics; healthy subjects ... See more keywords
Free volume distribution and structural inhomogeneity in Ni50V50 amorphous alloy
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DOI: 10.1016/j.jallcom.2018.08.148
Abstract: Abstract The structure of Ni 50 V 50 amorphous alloy was investigated by using neutron, X-ray diffraction and reverse Monte Carlo (RMC) modelling. The RMC configuration was decomposed into polyhedral holes whose faces are all… read more here.
Keywords: polyhedral holes; distribution structural; volume distribution; free volume ... See more keywords
Human Apparent Volume of Distribution Predicts Bioaccumulation of Ionizable Organic Chemicals in Zebrafish Embryos.
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DOI: 10.1021/acs.est.2c03421
Abstract: Chemicals with elevated bioaccumulation profiles present potential hazards to public health and the environment. Ionizable organic compounds (IOCs) increasingly represent a large proportion of commercial chemicals; however, historical approaches for bioaccumulation determinations are mainly developed… read more here.
Keywords: volume distribution; apparent volume; ionizable organic; bioaccumulation ... See more keywords
Evaluation of Tissue Binding in Three Tissues across Five Species and Prediction of Volume of Distribution from Plasma Protein and Tissue Binding with an Existing Model
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DOI: 10.1124/dmd.120.000337
Abstract: Volume of distribution (Vd) is a primary pharmacokinetic parameter used to calculate the half-life and plasma concentration-time profile of drugs. Numerous models have been relatively successful in predicting Vd, but the model developed by Korzekwa… read more here.
Keywords: tissue binding; volume distribution; plasma protein; model ... See more keywords