Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-0951-z
Abstract: Members of the leucine-rich repeat-containing 8 (LRRC8) protein family, composed of the five LRRC8A-E isoforms, are pore-forming components of the volume-regulated anion channel (VRAC). LRRC8A and at least one of the other LRRC8 isoforms assemble… read more here.
Keywords: lrrc8d isoform; regulated anion; isoform; structure ... See more keywords
The volume-regulated anion channel (LRRC8) in nodose neurons is sensitive to acidic pH.
Sign Up to like & getrecommendations! Published in 2017 at "JCI insight"
DOI: 10.1172/jci.insight.90632
Abstract: The leucine rich repeat containing protein 8A (LRRC8A), or SWELL1, is an essential component of the volume-regulated anion channel (VRAC) that is activated by cell swelling and ionic strength. We report here for the first… read more here.
Keywords: anion channel; nodose neurons; regulated anion; volume regulated ... See more keywords
Absolute Protein Amounts and Relative Abundance of Volume-regulated Anion Channel (VRAC) LRRC8 Subunits in Cells and Tissues Revealed by Quantitative Immunoblotting
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DOI: 10.3390/ijms20235879
Abstract: The volume-regulated anion channel (VRAC) plays an important role in osmotic cell volume regulation. In addition, it is involved in various physiological processes such as insulin secretion, glia-neuron communication and purinergic signaling. VRAC is formed… read more here.
Keywords: regulated anion; volume; channel; cell ... See more keywords
Structure of the human volume regulated anion channel
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.38461
Abstract: SWELL1 (LRRC8A) is the only essential subunit of the Volume Regulated Anion Channel (VRAC), which regulates cellular volume homeostasis and is activated by hypotonic solutions. SWELL1, together with four other LRRC8 family members, potentially forms… read more here.
Keywords: regulated anion; volume; anion channel; structure ... See more keywords