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   Articles with "volumetric absorptive" as a keyword



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Volumetric absorptive microsampling as an alternative sampling strategy for the determination of paracetamol in blood and cerebrospinal fluid

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recommendations! Published in 2018 at "Analytical and Bioanalytical Chemistry"

DOI: 10.1007/s00216-018-1427-6

Abstract: AbstractIn the field of bioanalysis, dried matrix spot sampling is increasingly receiving interest, as this alternative sampling strategy offers many potential benefits over traditional sampling, including matrix volume-sparing properties. By using a microsampling strategy, e.g.,… read more here.

Keywords: absorptive microsampling; volumetric absorptive; strategy; alternative sampling ... See more keywords
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Analysis of tamoxifen and its metabolites in dried blood spot and volumetric absorptive microsampling: comparison and clinical application

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recommendations! Published in 2021 at "Heliyon"

DOI: 10.1016/j.heliyon.2021.e07275

Abstract: This research was conducted to develop the Dried Blood Spot (DBS) and Volumetric Absorptive Microsampling (VAMS) method in the analysis of Tamoxifen (TAM) and its metabolites endoxifen (END), 4-hydroxytamoxifen (4-HT), and N-desmethyltamoxifen (NDT) using Ultra… read more here.

Keywords: absorptive microsampling; analysis; blood spot; volumetric absorptive ... See more keywords
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Application of volumetric absorptive microsampling device for quantification of tacrolimus in human blood as a model drug of high blood cell partition

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recommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"

DOI: 10.1016/j.jpba.2017.05.050

Abstract: &NA; Volumetric absorptive microsampling device (VAMS) was evaluated for bioanalysis of tacrolimus, which was used as a model drug with high blood cell partition. Aliquots of blood (ca. 10 &mgr;L) with different hematocrits and fortified… read more here.

Keywords: absorptive microsampling; volumetric absorptive; model drug; blood ... See more keywords
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Volumetric absorptive microsampling (VAMS) for the quantification of ten kinase inhibitors and determination of their in vitro VAMS-to-plasma ratio.

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recommendations! Published in 2022 at "Journal of pharmaceutical and biomedical analysis"

DOI: 10.1016/j.jpba.2022.114623

Abstract: Personalized dosing of kinase inhibitors (KI) might be beneficial in oral anti-cancer therapy to overcome individual pharmacokinetic variability. Volumetric absorptive microsampling (VAMS) has emerged as an attractive alternative compared to conventional invasive sampling methods enabling… read more here.

Keywords: volumetric absorptive; absorptive microsampling; microsampling vams; kinase inhibitors ... See more keywords
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Quantitation of phosphatidylethanol in dried blood after volumetric absorptive microsampling.

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recommendations! Published in 2021 at "Talanta"

DOI: 10.1016/j.talanta.2020.121694

Abstract: BACKGROUND Stimulated by the increased recognition of phosphatidylethanol (PEth) as sensitive direct marker of alcohol intake, the Ghent University's Laboratory of Toxicology and the National Institute of Criminalistics and Criminology combined their efforts to develop… read more here.

Keywords: dried blood; volumetric absorptive; toxicology; absorptive microsampling ... See more keywords
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Evaluation of Volumetric Absorptive Microsampling and Mass Spectrometry Data-Independent Acquisition of Hemoglobin-Related Clinical Markers.

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recommendations! Published in 2022 at "Journal of proteome research"

DOI: 10.1021/acs.jproteome.1c00892

Abstract: Data-independent acquisition (DIA) allows comprehensive proteome coverage, while it also potentially works as a unified protocol to determine a multitude of proteins found in blood. Because of its high specificity, mass spectrometry may greatly reduce… read more here.

Keywords: data independent; mass spectrometry; volumetric absorptive; independent acquisition ... See more keywords
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Volumetric Absorptive Microsampling as a New Biosampling Tool for Monitoring of Tamoxifen, Endoxifen, 4-OH Tamoxifen and N-Desmethyltamoxifen in Breast Cancer Patients

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recommendations! Published in 2021 at "Drug Design, Development and Therapy"

DOI: 10.2147/dddt.s286409

Abstract: Introduction In this research, we used a volumetric absorptive microsampling (VAMS) technique to collect blood samples from the patients. A rapid and simple sample preparation method and LC-MS.MS assay was then developed and validated for… read more here.

Keywords: volumetric absorptive; tamoxifen; tamoxifen endoxifen; desmethyltamoxifen ... See more keywords
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Development and validation of a UPLC-MS/MS method with volumetric absorptive microsampling to quantitate cyclophosphamide and 4-hydroxycyclophosphamide

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recommendations! Published in 2022 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2022.928721

Abstract: Cyclophosphamide (CP) is an anti-cancer alkylating prodrug, metabolized by CYP450 into its active metabolite 4-hydroxycyclophosphamide (4-OHCP). Its therapeutic effectiveness is determined by the 4-OHCP concentration. Several analytical methods in plasma and dried blood spots have… read more here.

Keywords: volumetric absorptive; method volumetric; absorptive microsampling; method ... See more keywords
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Volumetric Absorptive Microsampling in Therapeutic Drug Monitoring of Immunosuppressive Drugs—From Sampling and Analytical Issues to Clinical Application

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24010681

Abstract: Miniaturisation and simplification are novel approaches in clinical bioanalysis, especially in therapeutic drug monitoring (TDM). These contemporary trends are related to the sampling, pre-treatment, and analysis of biological fluids. Currently, dried blood spot (DBS), one… read more here.

Keywords: volumetric absorptive; therapeutic drug; drug monitoring; drug ... See more keywords
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Volumetric Absorptive Microsampling (VAMS) for Targeted LC-MS/MS Determination of Tryptophan-Related Biomarkers

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recommendations! Published in 2022 at "Molecules"

DOI: 10.3390/molecules27175652

Abstract: L-Tryptophan (TRP) metabolites and related biomarkers play crucial roles in physiological functions, and their imbalances are implicated in central nervous system pathologies and neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer’s disease, Parkinson’s disease,… read more here.

Keywords: related biomarkers; volumetric absorptive; microsampling vams; determination ... See more keywords
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Therapeutic Drug Monitoring of Tacrolimus Based on Volumetric Absorptive Microsampling Technique (VAMS) in Renal Transplant Pediatric Recipients—LC-MS/MS Method Development, Hematocrit Effect Evaluation, and Clinical Application

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recommendations! Published in 2023 at "Pharmaceutics"

DOI: 10.3390/pharmaceutics15010299

Abstract: Tacrolimus (TAC) is post-transplant pharmacotherapy’s most widely used immunosuppressant. In routine clinical practice, frequent uncomfortable venipuncture is necessary for whole-blood (WB) collection to check trough TAC levels. Volumetric absorptive microsampling (VAMS) is an alternative strategy… read more here.

Keywords: effect; volumetric absorptive; tacrolimus; hematocrit effect ... See more keywords