Nandrolone supplementation does not improve functional recovery in an aged animal model of volumetric muscle loss injury
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.3286
Abstract: Aging hinders the effectiveness of regenerative medicine strategies targeting the repair of volumetric muscle loss (VML) injury. Anabolic steroids have been shown to improve several factors which contribute to the age‐related decline in muscle's regenerative… read more here.
Keywords: volumetric muscle; muscle; aged animal; injury ... See more keywords
Evaluation of licofelone as an adjunct anti-inflammatory therapy to biologic scaffolds in the treatment of volumetric muscle loss.
Sign Up to like & getrecommendations! Published in 2021 at "Cell and tissue research"
DOI: 10.1007/s00441-021-03449-0
Abstract: Biologic scaffolds (BS) are the most widely studied therapeutics for the treatment of volumetric muscle loss (VML) owing to their purported effects on cell proliferation, chemotaxis, migration, and differentiation. Despite these claims, variability in reports… read more here.
Keywords: biologic scaffolds; treatment; licofelone; inflammatory ... See more keywords
Targeting intramuscular adipose tissue expansion to preserve contractile function in volumetric muscle loss: A potentially novel therapy?
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2021.03.006
Abstract: In volumetric muscle loss (VML), the severity of trauma exceeds a muscle's regenerative capacity. VML causes permanent functional impairments for which there are no rehabilitative, pharmacological, or regenerative medicine interventions. Driving failed regeneration in VML… read more here.
Keywords: intramuscular adipose; muscle; tissue; volumetric muscle ... See more keywords
Pre-innervated tissue-engineered muscle promotes a pro-regenerative microenvironment following volumetric muscle loss
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-1056-4
Abstract: Volumetric muscle loss (VML) is the traumatic or surgical loss of skeletal muscle beyond the inherent regenerative capacity of the body, generally leading to severe functional deficit. Formation of appropriate somato-motor innervations remains one of… read more here.
Keywords: muscle; volumetric muscle; engineered muscle; tissue engineered ... See more keywords
Spatiotemporal mapping of immune and stem cell dysregulation after volumetric muscle loss
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1101/2022.06.03.494707
Abstract: Volumetric muscle loss (VML) is an acute trauma that results in persistent inflammation, supplantation of muscle tissue with fibrotic scarring, and decreased muscle function. The cell types, nature of cellular communication and tissue locations that… read more here.
Keywords: cell; stem cell; volumetric muscle; muscle ... See more keywords
Early initiation of electrical stimulation paired with range of motion after a volumetric muscle loss injury does not benefit muscle function
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Physiology"
DOI: 10.1113/ep090630
Abstract: What is the central question of this study? First, how does physical rehabilitation influence recovery from traumatic muscle injury? Second, how does physical activity impact the rehabilitation response for skeletal muscle function and whole‐body metabolism?… read more here.
Keywords: volumetric muscle; muscle function; muscle; range motion ... See more keywords
Biofabricating murine and human myo‐substitutes for rapid volumetric muscle loss restoration
Sign Up to like & getrecommendations! Published in 2021 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202012778
Abstract: The importance of skeletal muscle tissue is undoubted being the controller of several vital functions including respiration and all voluntary locomotion activities. However, its regenerative capability is limited and significant tissue loss often leads to… read more here.
Keywords: muscle; volumetric muscle; muscle loss; myo substitutes ... See more keywords
Human muscle in gene edited pigs for treatment of volumetric muscle loss
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.948496
Abstract: Focusing on complex extremity trauma and volumetric muscle loss (VML) injuries, this review highlights: 1) the current pathophysiologic limitations of the injury sequela; 2) the gene editing strategy of the pig as a model that… read more here.
Keywords: volumetric muscle; muscle; muscle loss; gene edited ... See more keywords
The bioenergetic “CK Clamp” technique detects substrate-specific changes in mitochondrial respiration and membrane potential during early VML injury pathology
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1178213
Abstract: Volumetric muscle loss (VML) injuries are characterized by non-recoverable loss of tissue resulting in contractile and metabolic dysfunction. The characterization of metabolic dysfunction in volumetric muscle loss-injured muscle has been interpreted from permeabilized myofiber respiration… read more here.
Keywords: membrane potential; volumetric muscle; loss; muscle ... See more keywords