Articles with "volunteers patients" as a keyword



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Population Pharmacokinetics of Oral Brepocitinib in Healthy Volunteers and Patients

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Published in 2022 at "Clinical Pharmacology in Drug Development"

DOI: 10.1002/cpdd.1163

Abstract: Brepocitinib is a tyrosine kinase 2 and Janus kinase 1 inhibitor in development for treatment of inflammatory autoimmune diseases. This analysis aimed to add to the pharmacokinetic knowledge of the medication, through development of a… read more here.

Keywords: volunteers patients; healthy volunteers; brepocitinib; model ... See more keywords
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Spectral diffusion analysis of kidney intravoxel incoherent motion MRI in healthy volunteers and patients with renal pathologies

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Published in 2021 at "Magnetic Resonance in Medicine"

DOI: 10.1002/mrm.28631

Abstract: To assess the feasibility of measuring tubular and vascular signal fractions in the human kidney using nonnegative least‐square (NNLS) analysis of intravoxel incoherent motion data collected in healthy volunteers and patients with renal pathologies. read more here.

Keywords: intravoxel incoherent; renal pathologies; patients renal; healthy volunteers ... See more keywords
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A Systematic Review and Meta-analysis of Isoniazid Pharmacokinetics in Healthy Volunteers and Patients with Tuberculosis.

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Published in 2020 at "Clinical therapeutics"

DOI: 10.1016/j.clinthera.2020.09.009

Abstract: PURPOSE This systematic review and meta-analysis assesses the pharmacokinetic (PK) summary estimates of isoniazid (INH) between healthy volunteers and patients with tuberculosis (TB), evaluates whether the current INH dose regimen is appropriate in patients with… read more here.

Keywords: cmax auc; systematic review; healthy volunteers; volunteers patients ... See more keywords
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Grapefruit juice prolongs the QT interval of healthy volunteers and patients with long QT syndrome.

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Published in 2019 at "Heart rhythm"

DOI: 10.1016/j.hrthm.2019.04.039

Abstract: BACKGROUND The list of medications linked to drug-induced long QT syndrome (LQTS) is diverse. It is possible that food products too have QT-prolonging potential. OBJECTIVE We tested the effects of grapefruit juice on the QT… read more here.

Keywords: long syndrome; grapefruit; healthy volunteers; grapefruit juice ... See more keywords
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In Vitro Effect of Combined Hypertonic Saline and Salbutamol on Ciliary Beating Frequency and Mucociliary Transport in Human Nasal Epithelial Cells of Healthy Volunteers and Patients with Cystic Fibrosis.

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Published in 2023 at "Journal of aerosol medicine and pulmonary drug delivery"

DOI: 10.1089/jamp.2022.0026

Abstract: Background: Inhalation of hypertonic saline (HS) is standard of care in patients with cystic fibrosis (CF). However, it is unclear if adding salbutamol has-besides bronchodilation-further benefits, for example, on the mucociliary clearance. We assessed this… read more here.

Keywords: volunteers patients; healthy volunteers; effect; cbf ... See more keywords
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Fat fraction quantification of bone marrow in the lumbar spine using the LiverLab assessment tool in healthy adult volunteers and patients with Gaucher Disease.

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Published in 2022 at "Internal medicine journal"

DOI: 10.1111/imj.15858

Abstract: AIMS Magnetic Resonance Imaging (MRI) is used for evaluation of bone in Gaucher disease (GD), but a widely available quantitative scoring method remains elusive. The study purpose was to assess the reproducibility of the LiverLab… read more here.

Keywords: volunteers patients; bone marrow; bone; gaucher disease ... See more keywords
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Clinical experience with isavuconazole in healthy volunteers and patients with invasive aspergillosis in China, and the results from an exposure–response analysis

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Published in 2020 at "Mycoses"

DOI: 10.1111/myc.13233

Abstract: Isavuconazole is a broad‐spectrum triazole for the treatment of invasive fungal disease (IFD). read more here.

Keywords: isavuconazole healthy; experience isavuconazole; healthy volunteers; patients invasive ... See more keywords
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Pharmacokinetic Characteristics of Siponimod in Healthy Volunteers and Patients With Multiple Sclerosis: Analyses of Published Clinical Trials

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Published in 2022 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2022.824232

Abstract: Objectives: This study aimed to investigate the pharmacokinetic characteristics of siponimod in healthy volunteers and patients with MS based on aggregated data from published clinical trials, and to explore the factors influencing siponimod exposure. Methods:… read more here.

Keywords: published clinical; volunteers patients; healthy volunteers; clinical trials ... See more keywords