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Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1163
Abstract: Brepocitinib is a tyrosine kinase 2 and Janus kinase 1 inhibitor in development for treatment of inflammatory autoimmune diseases. This analysis aimed to add to the pharmacokinetic knowledge of the medication, through development of a…
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Keywords:
volunteers patients;
healthy volunteers;
brepocitinib;
model ... See more keywords
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Published in 2021 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.28631
Abstract: To assess the feasibility of measuring tubular and vascular signal fractions in the human kidney using nonnegative least‐square (NNLS) analysis of intravoxel incoherent motion data collected in healthy volunteers and patients with renal pathologies.
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Keywords:
intravoxel incoherent;
renal pathologies;
patients renal;
healthy volunteers ... See more keywords
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Published in 2020 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2020.09.009
Abstract: PURPOSE This systematic review and meta-analysis assesses the pharmacokinetic (PK) summary estimates of isoniazid (INH) between healthy volunteers and patients with tuberculosis (TB), evaluates whether the current INH dose regimen is appropriate in patients with…
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Keywords:
cmax auc;
systematic review;
healthy volunteers;
volunteers patients ... See more keywords
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Published in 2019 at "Heart rhythm"
DOI: 10.1016/j.hrthm.2019.04.039
Abstract: BACKGROUND The list of medications linked to drug-induced long QT syndrome (LQTS) is diverse. It is possible that food products too have QT-prolonging potential. OBJECTIVE We tested the effects of grapefruit juice on the QT…
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Keywords:
long syndrome;
grapefruit;
healthy volunteers;
grapefruit juice ... See more keywords
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Published in 2023 at "Journal of aerosol medicine and pulmonary drug delivery"
DOI: 10.1089/jamp.2022.0026
Abstract: Background: Inhalation of hypertonic saline (HS) is standard of care in patients with cystic fibrosis (CF). However, it is unclear if adding salbutamol has-besides bronchodilation-further benefits, for example, on the mucociliary clearance. We assessed this…
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Keywords:
volunteers patients;
healthy volunteers;
effect;
cbf ... See more keywords
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Published in 2022 at "Internal medicine journal"
DOI: 10.1111/imj.15858
Abstract: AIMS Magnetic Resonance Imaging (MRI) is used for evaluation of bone in Gaucher disease (GD), but a widely available quantitative scoring method remains elusive. The study purpose was to assess the reproducibility of the LiverLab…
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Keywords:
volunteers patients;
bone marrow;
bone;
gaucher disease ... See more keywords
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Published in 2020 at "Mycoses"
DOI: 10.1111/myc.13233
Abstract: Isavuconazole is a broad‐spectrum triazole for the treatment of invasive fungal disease (IFD).
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Keywords:
isavuconazole healthy;
experience isavuconazole;
healthy volunteers;
patients invasive ... See more keywords
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Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.824232
Abstract: Objectives: This study aimed to investigate the pharmacokinetic characteristics of siponimod in healthy volunteers and patients with MS based on aggregated data from published clinical trials, and to explore the factors influencing siponimod exposure. Methods:…
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Keywords:
published clinical;
volunteers patients;
healthy volunteers;
clinical trials ... See more keywords