UPLC-MS/MS for simultaneous quantification of vortioxetine and its metabolite Lu AA34443 in rat plasma and its application to drug interactions
Sign Up to like & getrecommendations! Published in 2020 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2020.09.056
Abstract: Abstract Vortioxetine is currently used as the first-line therapy drug for major depressive disorder (MDD). In the present study, we aimed to develop and fully validate an ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS)… read more here.
Keywords: vortioxetine; drug; simultaneous quantification; metabolite aa34443 ... See more keywords
The rat hippocampal gliovascular system following one week vortioxetine and fluoxetine
Sign Up to like & getrecommendations! Published in 2021 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2020.11.008
Abstract: We have previously reported that vortioxetine, unlike the selective serotonin reuptake inhibitor fluoxetine, produces a rapid increase of dendritic spine number and Brain Derived Neurotrophic Factor (BDNF)-associated formation of synapses with mitochondrial support in the… read more here.
Keywords: rat hippocampal; vortioxetine; week vortioxetine; fluoxetine ... See more keywords
Vortioxetine 5, 10, and 20 mg Significantly Reduces the Risk of Relapse Compared With Placebo in Patients With Remitted Major Depressive Disorder: The RESET Study.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of affective disorders"
DOI: 10.1016/j.jad.2022.02.002
Abstract: BACKGROUND Maintenance therapy for major depressive disorder (MDD) is typically recommended at the dose on which the patient was stabilized. However, for some patients, dose alteration may be required. We investigated multiple vortioxetine doses versus… read more here.
Keywords: vortioxetine; placebo; depressive disorder; relapse ... See more keywords
Effect of vortioxetine vs. escitalopram on plasma BDNF and platelet serotonin in depressed patients
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2020.110016
Abstract: Escitalopram and vortioxetine are efficacious antidepressants. They directly target serotonin (5-HT) system, but vortioxetine mechanism of action is distinct from the one of selective serotonin reuptake inhibitors (SSRIs). Treatment with SSRIs decrease platelet 5-HT concentration… read more here.
Keywords: vortioxetine; plasma bdnf; platelet concentration; concentration ... See more keywords
Assessment in Work Productivity and the Relationship with Cognitive Symptoms (AtWoRC): primary analysis from a Canadian open-label study of vortioxetine in patients with major depressive disorder (MDD)
Sign Up to like & getrecommendations! Published in 2018 at "CNS Spectrums"
DOI: 10.1017/s1092852918000913
Abstract: Objective The Assessment in Work Productivity and the Relationship with Cognitive Symptoms (AtWoRC) study aimed to assess the association between cognitive symptoms and work productivity in gainfully employed patients receiving vortioxetine for a major depressive… read more here.
Keywords: vortioxetine; productivity; major depressive; work productivity ... See more keywords
Effect of clinically relevant doses of vortioxetine and citalopram on serotonergic PET markers in the nonhuman primate brain
Sign Up to like & getrecommendations! Published in 2019 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-019-0442-4
Abstract: Vortioxetine is a multimodal antidepressant approved for treatment of major depressive disorder. Preclinical studies have demonstrated that the mechanism of action of vortioxetine might be different from selective serotonin reuptake inhibitors (SSRIs), including larger serotonin… read more here.
Keywords: vortioxetine; pet; relevant doses; effect ... See more keywords
Vortioxetine in major depressive disorder: from mechanisms of action to clinical studies. An updated review.
Sign Up to like & getrecommendations! Published in 2021 at "Expert opinion on drug safety"
DOI: 10.1080/14740338.2022.2019705
Abstract: INTRODUCTION Vortioxetine is a multimodal-acting antidepressant that provides improvements on cognitive function aside from antidepressants and anxiolytic effects. Vortioxetine has been found to be one of the most effective and best tolerated options for major… read more here.
Keywords: action; vortioxetine; depressive disorder; clinical studies ... See more keywords
Vortioxetine: a novel antidepressant for the treatment of major depressive disorder
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2019.1546691
Abstract: ABSTRACT Introduction: Vortioxetine is a novel antidepressant drug approved for the treatment of major depressive disorder (MDD) in adults. It is formulated into tablets and has a dose range of 5–20 mg. The recommended starting… read more here.
Keywords: vortioxetine; depressive disorder; treatment major; major depressive ... See more keywords
Acneiform eruption associated with the use of vortioxetine
Sign Up to like & getrecommendations! Published in 2019 at "Psychiatry and Clinical Psychopharmacology"
DOI: 10.1080/24750573.2018.1464633
Abstract: ABSTRACT Acneiform is used to describe eruptions that resemble acne vulgaris, but are not aetiologically similar. A number of drugs that can be responsible for acneiform eruptions exist. Vortioxetine is a multimodal antidepressant molecule that… read more here.
Keywords: vortioxetine; acneiform eruption; eruption associated; associated use ... See more keywords
Association Between CYP2D6 Metabolizer Status and Vortioxetine Exposure and Treatment Switching
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Psychopharmacology"
DOI: 10.1097/jcp.0000000000001563
Abstract: Abstract Purpose The antidepressant vortioxetine is mainly metabolized by the polymorphic enzyme CYP2D6. The aim of this study was to investigate the absolute serum concentrations of vortioxetine and frequency of switching to an alternative antidepressant… read more here.
Keywords: vortioxetine exposure; association cyp2d6; cyp2d6; vortioxetine ... See more keywords
Development and validation of a LC–MS/MS method for analysis of vortioxetine in postmortem specimens. First data from an authentic case
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Forensic Sciences"
DOI: 10.1111/1556-4029.15198
Abstract: Vortioxetine is an antidepressant recently licensed in USA and EU for the treatment of major depressive disorder. Neither fatal case due to overdose nor data about postmortem concentrations on blood or other specimens have been… read more here.
Keywords: postmortem; vortioxetine; analysis; case ... See more keywords