Molecular dynamics exploration of the binding mechanism and properties of single-walled carbon nanotube to WT and mutant VP35 FBP region of Ebola virus
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biological Physics"
DOI: 10.1007/s10867-016-9440-5
Abstract: VP35 of Ebola viruses (EBOVs) is an attractive potential target because of its multifunction. All-atom molecular dynamics (MD) simulations and Molecular Mechanics Generalized Born surface area (MM/GBSA) energy calculations are performed to investigate the single-walled… read more here.
Keywords: molecular dynamics; walled carbon; carbon nanotube; single walled ... See more keywords
Insights into the homo-oligomerization properties of N-terminal coiled-coil domain of Ebola virus VP35 protein.
Sign Up to like & getrecommendations! Published in 2018 at "Virus research"
DOI: 10.1016/j.virusres.2018.02.003
Abstract: The multifunctional Ebola virus (EBOV) VP35 protein is a key determinant of virulence. VP35 is essential for EBOV replication, is a component of the viral RNA polymerase and participates in nucleocapsid formation. Furthermore, VP35 contributes… read more here.
Keywords: homo oligomerization; ebola virus; vp35; vp35 protein ... See more keywords
Ubiquitination of Ebola virus VP35 at lysine 309 regulates viral transcription and assembly
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010532
Abstract: Ebola virus (EBOV) VP35 is a polyfunctional protein involved in viral genome packaging, viral polymerase function, and host immune antagonism. The mechanisms regulating VP35’s engagement in different functions are not well-understood. We previously showed that… read more here.
Keywords: ebola virus; viral transcription; ubiquitination; vp35 ... See more keywords