A methodological proof-of-concept of the teeter-totter effect
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Sports Sciences"
DOI: 10.1080/02640414.2024.2394746
Abstract: ABSTRACT The Nike Vaporfly 4% (VP4) shoe is popular due to its unique design and reported performance benefits. However, the underlying mechanisms responsible for the improvements remain unclear. One proposed mechanism is the teeter-totter effect.… read more here.
Keywords: totter effect; teeter; teeter totter; vp4 ... See more keywords
A Point Mutation in the Rhesus Rotavirus VP4 Protein Generated through a Rotavirus Reverse Genetics System Attenuates Biliary Atresia in the Murine Model
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.00510-17
Abstract: ABSTRACT Rotavirus infection is one of the most common causes of diarrheal illness in humans. In neonatal mice, rhesus rotavirus (RRV) can induce biliary atresia (BA), a disease resulting in inflammatory obstruction of the extrahepatic… read more here.
Keywords: genetics; rotavirus; biliary atresia; vp4 ... See more keywords
Structure, Immunogenicity, and Protective Mechanism of an Engineered Enterovirus 71-Like Particle Vaccine Mimicking 80S Empty Capsid
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.01330-17
Abstract: ABSTRACT Enterovirus 71 (EV71) is the major causative agent of severe hand, foot, and mouth disease, which affects millions of young children in the Asia-Pacific region annually. In this study, we engineered a novel EV71… read more here.
Keywords: particle; vp4; structure; capsid ... See more keywords
Grass carp reovirus VP4 manipulates TOLLIP to degrade STING for inhibition of IFN production
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Virology"
DOI: 10.1128/jvi.01583-24
Abstract: ABSTRACT Although fish possess an effective interferon (IFN) system to defend against viral infection, grass carp reovirus (GCRV) still causes epidemic hemorrhagic disease and tremendous economic loss in grass carp. Therefore, it is necessary to… read more here.
Keywords: grass carp; carp reovirus; vp4; ifn ... See more keywords
Does the Evidence Support the Existence of the Simian Polyomavirus SV40 Vp4 Viroporin?
Sign Up to like & getrecommendations! Published in 2020 at "mSphere"
DOI: 10.1128/msphere.00019-20
Abstract: The simian polyomavirus SV40 was reported to express Vp4, an N-terminally truncated form of the minor capsid proteins Vp2 and Vp3. Since a missense mutation of the putative Vp4 start codon (Vp2M228I) was found to… read more here.
Keywords: sv40; polyomavirus sv40; simian polyomavirus; release ... See more keywords
In Support of Simian Polyomavirus 40 VP4 as a Later Expressed Viroporin
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DOI: 10.1128/msphere.00187-20
Abstract: Simian virus 40 VP4 was discovered in 2007 as a later expressed viral protein initiated from a downstream Met on the VP2/VP3 transcript. VP4’s role as a viroporin involved in viral release was supported in… read more here.
Keywords: later expressed; vp4 later; polyomavirus vp4; simian polyomavirus ... See more keywords
Evaluation of VP4-VP2 sequencing for molecular typing of human enteroviruses
Sign Up to like & getrecommendations! Published in 2024 at "PLOS ONE"
DOI: 10.1371/journal.pone.0311806
Abstract: Enteroviruses and rhinoviruses are highly diverse, with over 300 identified types. Reverse transcription-polymerase chain reaction (RT-PCR) assays targeting their VP1, VP4, and partial VP2 (VP4-pVP2) genomic regions are used for detection and identification. The VP4-pVP2… read more here.
Keywords: vp4 pvp2; vp2 sequencing; evaluation vp4; vp4 vp2 ... See more keywords
Case Report: Successful Surgical Resection of PVTT Vp4 Hepatocellular Carcinoma Following Hepatic Arterial Infusion Chemotherapy Combined with Cadonilimab Plus Donafenib
Sign Up to like & getrecommendations! Published in 2025 at "Pharmacogenomics and Personalized Medicine"
DOI: 10.2147/pgpm.s555061
Abstract: Objective To evaluate the potential and efficacy of hepatic artery infusion chemotherapy combined with the PD-1/CTLA-4 bispecific antibody cadonilimab and the multi-kinase inhibitor donafenib in conversion therapy for unresectable hepatocellular carcinoma (uHCC) with Vp4-type portal… read more here.
Keywords: hepatocellular carcinoma; infusion chemotherapy; vp4;
Generation of Antibodies against Foot-and-Mouth-Disease Virus Capsid Protein VP4 Using Hepatitis B Core VLPs as a Scaffold
Sign Up to like & getrecommendations! Published in 2021 at "Life"
DOI: 10.3390/life11040338
Abstract: The picornavirus foot-and-mouth disease virus (FMDV) is the causative agent of the economically important disease of livestock, foot-and-mouth disease (FMD). VP4 is a highly conserved capsid protein, which is important during virus entry. Previous published… read more here.
Keywords: foot mouth; vp4; capsid; mouth disease ... See more keywords
VP4 Mutation Boosts Replication of Recombinant Human/Simian Rotavirus in Cell Culture
Sign Up to like & getrecommendations! Published in 2024 at "Viruses"
DOI: 10.3390/v16040565
Abstract: Rotavirus A (RVA) is the leading cause of diarrhea requiring hospitalization in children and causes over 100,000 annual deaths in Sub-Saharan Africa. In order to generate next-generation vaccines against African RVA genotypes, a reverse genetics… read more here.
Keywords: simian rotavirus; cell culture; culture; mutation ... See more keywords
Establishment of Sandwich ELISA for Quality Control in Rotavirus Vaccine Production
Sign Up to like & getrecommendations! Published in 2022 at "Vaccines"
DOI: 10.3390/vaccines10020243
Abstract: Non-replicating rotavirus vaccines are alternative strategies that may improve the protective efficacy of rotavirus vaccines in low- and middle-income countries. The truncated spike protein VP4 (aa26-476, VP4*)was a candidate antigen for the development of recombinant… read more here.
Keywords: quality control; development; vp4; rotavirus ... See more keywords