A Point Mutation in the Rhesus Rotavirus VP4 Protein Generated through a Rotavirus Reverse Genetics System Attenuates Biliary Atresia in the Murine Model
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.00510-17
Abstract: ABSTRACT Rotavirus infection is one of the most common causes of diarrheal illness in humans. In neonatal mice, rhesus rotavirus (RRV) can induce biliary atresia (BA), a disease resulting in inflammatory obstruction of the extrahepatic… read more here.
Keywords: genetics; rotavirus; biliary atresia; vp4 ... See more keywords
Structure, Immunogenicity, and Protective Mechanism of an Engineered Enterovirus 71-Like Particle Vaccine Mimicking 80S Empty Capsid
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.01330-17
Abstract: ABSTRACT Enterovirus 71 (EV71) is the major causative agent of severe hand, foot, and mouth disease, which affects millions of young children in the Asia-Pacific region annually. In this study, we engineered a novel EV71… read more here.
Keywords: particle; vp4; structure; capsid ... See more keywords
Does the Evidence Support the Existence of the Simian Polyomavirus SV40 Vp4 Viroporin?
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DOI: 10.1128/msphere.00019-20
Abstract: The simian polyomavirus SV40 was reported to express Vp4, an N-terminally truncated form of the minor capsid proteins Vp2 and Vp3. Since a missense mutation of the putative Vp4 start codon (Vp2M228I) was found to… read more here.
Keywords: sv40; polyomavirus sv40; simian polyomavirus; release ... See more keywords
In Support of Simian Polyomavirus 40 VP4 as a Later Expressed Viroporin
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DOI: 10.1128/msphere.00187-20
Abstract: Simian virus 40 VP4 was discovered in 2007 as a later expressed viral protein initiated from a downstream Met on the VP2/VP3 transcript. VP4’s role as a viroporin involved in viral release was supported in… read more here.
Keywords: later expressed; vp4 later; polyomavirus vp4; simian polyomavirus ... See more keywords
Generation of Antibodies against Foot-and-Mouth-Disease Virus Capsid Protein VP4 Using Hepatitis B Core VLPs as a Scaffold
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DOI: 10.3390/life11040338
Abstract: The picornavirus foot-and-mouth disease virus (FMDV) is the causative agent of the economically important disease of livestock, foot-and-mouth disease (FMD). VP4 is a highly conserved capsid protein, which is important during virus entry. Previous published… read more here.
Keywords: foot mouth; vp4; capsid; mouth disease ... See more keywords
Establishment of Sandwich ELISA for Quality Control in Rotavirus Vaccine Production
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DOI: 10.3390/vaccines10020243
Abstract: Non-replicating rotavirus vaccines are alternative strategies that may improve the protective efficacy of rotavirus vaccines in low- and middle-income countries. The truncated spike protein VP4 (aa26-476, VP4*)was a candidate antigen for the development of recombinant… read more here.
Keywords: quality control; development; vp4; rotavirus ... See more keywords
Auxotrophic Lactobacillus Expressing Porcine Rotavirus VP4 Constructed Using CRISPR-Cas9D10A System Induces Effective Immunity in Mice
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DOI: 10.3390/vaccines10091510
Abstract: Porcine rotavirus (PoRV) mainly causes acute diarrhea in piglets under eight weeks of age and has potentially high morbidity and mortality rates. As vaccine carriers for oral immunization, lactic acid bacteria (LAB) are an ideal… read more here.
Keywords: porcine rotavirus; vp4; alr vp4; alr ... See more keywords