Metabolite profiling of whole murine embryos reveals metabolic perturbations associated with maternal valproate-induced neural tube closure defects.
Sign Up to like & getrecommendations! Published in 2017 at "Birth defects research"
DOI: 10.1002/bdra.23583
Abstract: BACKGROUND Valproic acid (VPA) is prescribed therapeutically for multiple conditions, including epilepsy. When taken during pregnancy, VPA is teratogenic, increasing the risk of several birth and developmental defects including neural tube defects (NTDs). The mechanism… read more here.
Keywords: vpa; embryos; neural tube; tube closure ... See more keywords
Cell Death Mode Switching Between Apoptosis and Autophagy by Inhibitory Level of Histone Deacetylase 6.
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200614
Abstract: Inhibition of histone deacetylase (HDAC) has been demonstrated to be an effective strategy for cancer treatment. In this work, we have developed a new agent Ir-VPA, which exhibits the cell death mode switching between apoptosis and… read more here.
Keywords: cell death; death mode; apoptosis; mode switching ... See more keywords
Developmental Trajectory of Autistic-Like Behaviors in a Prenatal Valproic Acid Rat Model of Autism.
Sign Up to like & getrecommendations! Published in 2024 at "Developmental psychobiology"
DOI: 10.1002/dev.70008
Abstract: Autism spectrum disorders (ASDs) are characterized by deficits in social functioning, stereotyped patterns of behaviors, narrowed interests, and elevated anxiety. Certain ASD symptoms can persist, whereas others may improve throughout the lifespan, but the specific… read more here.
Keywords: vpa; recognition; model; rat model ... See more keywords
Cannabis Oil Protects Against Valproic Acid–Induced Autism Spectrum Disorder by Reducing Oxidative Stress
Sign Up to like & getrecommendations! Published in 2025 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22969
Abstract: Autism spectrum disorder (ASD) is characterized by persistent problems in speech, social interaction, restricted and repetitive behavior patterns, lack of interest, and intellectual disabilities. Currently, there is no effective treatment available for the core symptoms… read more here.
Keywords: cbd oil; vpa; spectrum disorder; autism spectrum ... See more keywords
Gene expression profiles of multiple brain regions in rats differ between developmental and postpubertal exposure to valproic acid
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4263
Abstract: We have previously reported that the valproic acid (VPA)‐induced disruption pattern of hippocampal adult neurogenesis differs between developmental and 28‐day postpubertal exposure. In the present study, we performed brain region‐specific global gene expression profiling to… read more here.
Keywords: expression; vpa; brain regions; exposure ... See more keywords
Vinpocetine Alleviates Valproic Acid‐Induced Hepatotoxicity and Neurotoxicity Through Activation of cAMP and PI3K/AKT/CREB Pathway in Rats
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70316
Abstract: Valproic acid (VPA) is a frequently prescribed treatment for many psychiatric disorders, particularly for epilepsy. However, it has been associated with possible side effects including hepatotoxicity and neurotoxicity. The present study investigated the protective effect… read more here.
Keywords: vpa; camp; creb; pi3k akt ... See more keywords
Ferroptosis and Lipid Peroxidation Participate in Valproic Acid‐Induced Hepatotoxicity via the Long‐chain Acyl‐CoA Synthetase 4/Glutathione Peroxidase 4 Pathway
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70484
Abstract: Valproic acid (VPA) is a commonly prescribed antiepileptic drug, with hepatotoxicity being one of its most frequent and severe adverse effects. The underlying mechanisms of VPA‐induced hepatotoxicity remain elusive. Thus, this study aimed to investigate… read more here.
Keywords: vpa; induced hepatotoxicity; vpa induced; ferroptosis ... See more keywords
Valproic acid promotes mitochondrial dysfunction in primary human hepatocytes in vitro; impact of C/EBPα-controlled gene expression
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Toxicology"
DOI: 10.1007/s00204-020-02835-x
Abstract: Valproic acid (VPA) is a frequently prescribed anti-epileptic drug which is known to cause liver toxicity and steatosis through mitochondrial dysfunction. Nevertheless the mechanisms underlying these adverse effects are incompletely understood. In this study, we… read more here.
Keywords: vpa exposure; gene; vpa; mitochondrial dysfunction ... See more keywords
Heart malformation is an early response to valproic acid in developing zebrafish
Sign Up to like & getrecommendations! Published in 2020 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-020-01949-4
Abstract: Valproic acid (VPA) is a branched short-chain fatty acid primarily used in epilepsy, but is also used in bipolar disorder, migraine, and psychotic disorders. Despite its wide range of use, it is a teratogen resulting… read more here.
Keywords: hpf; vpa; heart; hpf hpf ... See more keywords
Subtherapeutic valproic acid plasma concentrations under concomitant dipyrone therapy in an epilepsy patient—a case report
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-018-2417-5
Abstract: Valproic acid (VPA) is used as a broad anticonvulsant in the treatment of general and focal epilepsy and as maintenance therapy in bipolar disorder [1, 2]. Its effects are mediated by a blockage of voltage-gated… read more here.
Keywords: vpa; valproic acid; pcvpa; therapy ... See more keywords
Sodium valproate modulates immune response by alternative activation of monocyte-derived macrophages in systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Rheumatology"
DOI: 10.1007/s10067-017-3922-0
Abstract: The anti-inflammatory role of macrophages in apoptotic cells (ACs) clearance is involved in Systemic Lupus Erythematosus (SLE) pathogenesis. The efferocytic capability of macrophages is altered by M1/M2 polarization. Histone deacetylase inhibitors (HDACi) are proposed to… read more here.
Keywords: anti inflammatory; vpa; response; systemic lupus ... See more keywords