Metabolite profiling of whole murine embryos reveals metabolic perturbations associated with maternal valproate-induced neural tube closure defects.
Sign Up to like & getrecommendations! Published in 2017 at "Birth defects research"
DOI: 10.1002/bdra.23583
Abstract: BACKGROUND Valproic acid (VPA) is prescribed therapeutically for multiple conditions, including epilepsy. When taken during pregnancy, VPA is teratogenic, increasing the risk of several birth and developmental defects including neural tube defects (NTDs). The mechanism… read more here.
Keywords: vpa; embryos; neural tube; tube closure ... See more keywords
Cell Death Mode Switching Between Apoptosis and Autophagy by Inhibitory Level of Histone Deacetylase 6.
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200614
Abstract: Inhibition of histone deacetylase (HDAC) has been demonstrated to be an effective strategy for cancer treatment. In this work, we have developed a new agent Ir-VPA, which exhibits the cell death mode switching between apoptosis and… read more here.
Keywords: cell death; death mode; apoptosis; mode switching ... See more keywords
Gene expression profiles of multiple brain regions in rats differ between developmental and postpubertal exposure to valproic acid
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4263
Abstract: We have previously reported that the valproic acid (VPA)‐induced disruption pattern of hippocampal adult neurogenesis differs between developmental and 28‐day postpubertal exposure. In the present study, we performed brain region‐specific global gene expression profiling to… read more here.
Keywords: expression; vpa; brain regions; exposure ... See more keywords
Valproic acid promotes mitochondrial dysfunction in primary human hepatocytes in vitro; impact of C/EBPα-controlled gene expression
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Toxicology"
DOI: 10.1007/s00204-020-02835-x
Abstract: Valproic acid (VPA) is a frequently prescribed anti-epileptic drug which is known to cause liver toxicity and steatosis through mitochondrial dysfunction. Nevertheless the mechanisms underlying these adverse effects are incompletely understood. In this study, we… read more here.
Keywords: vpa exposure; gene; vpa; mitochondrial dysfunction ... See more keywords
Heart malformation is an early response to valproic acid in developing zebrafish
Sign Up to like & getrecommendations! Published in 2020 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-020-01949-4
Abstract: Valproic acid (VPA) is a branched short-chain fatty acid primarily used in epilepsy, but is also used in bipolar disorder, migraine, and psychotic disorders. Despite its wide range of use, it is a teratogen resulting… read more here.
Keywords: hpf; vpa; heart; hpf hpf ... See more keywords
Subtherapeutic valproic acid plasma concentrations under concomitant dipyrone therapy in an epilepsy patient—a case report
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-018-2417-5
Abstract: Valproic acid (VPA) is used as a broad anticonvulsant in the treatment of general and focal epilepsy and as maintenance therapy in bipolar disorder [1, 2]. Its effects are mediated by a blockage of voltage-gated… read more here.
Keywords: vpa; valproic acid; pcvpa; therapy ... See more keywords
Sodium valproate modulates immune response by alternative activation of monocyte-derived macrophages in systemic lupus erythematosus
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Rheumatology"
DOI: 10.1007/s10067-017-3922-0
Abstract: The anti-inflammatory role of macrophages in apoptotic cells (ACs) clearance is involved in Systemic Lupus Erythematosus (SLE) pathogenesis. The efferocytic capability of macrophages is altered by M1/M2 polarization. Histone deacetylase inhibitors (HDACi) are proposed to… read more here.
Keywords: anti inflammatory; vpa; response; systemic lupus ... See more keywords
Efficacy and Safety of Valproic Acid for Spinal Muscular Atrophy: A Systematic Review and Meta-Analysis
Sign Up to like & getrecommendations! Published in 2019 at "CNS Drugs"
DOI: 10.1007/s40263-019-00606-6
Abstract: BackgroundSpinal muscular atrophy (SMA) is a neuromuscular disorder classified into four types based on the age of onset of the disease. Early onset is correlated with a higher mortality rate, mainly due to respiratory complications.… read more here.
Keywords: vpa; efficacy safety; treatment; motor ... See more keywords
Valproic Acid Induced Neurotoxicological Manifestations and its Mitigation by Melatonin in Rat Brain Synaptosomes.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of medical research"
DOI: 10.1016/j.arcmed.2019.01.004
Abstract: BACKGROUND AND AIMS A short branched chain fatty acid, valproic acid (VPA), has been used worldwide for decades in the intervention of seizure disorders, neuropathic pain and migraine. However, several adverse effects of VPA have… read more here.
Keywords: melatonin; rat brain; vpa; valproic acid ... See more keywords
Association between the perturbation of bile acid homeostasis and valproic acid-induced hepatotoxicity.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.113669
Abstract: Valproic acid (VPA), a widely prescribed antiepileptic drug, is known to induce hepatotoxicity. However, the mechanisms underlying this toxicity are not well understood. In this study, we performed a nontargeted metabolomic analysis of children with… read more here.
Keywords: vpa; acid homeostasis; hepatotoxicity; bile acid ... See more keywords
Frequency and duration of vigorous physical activity bouts are associated with adolescent boys' bone mineral status: A cross-sectional study.
Sign Up to like & getrecommendations! Published in 2019 at "Bone"
DOI: 10.1016/j.bone.2018.10.019
Abstract: PURPOSE Vigorous physical activity (VPA) has been proven to promote osteogenesis in adolescents; however the specifics of the optimal pattern of frequency and duration of VPA are unknown. The main goal of the present study… read more here.
Keywords: bone mineral; vpa; frequency duration; vigorous physical ... See more keywords