Valproic acid promotes mitochondrial dysfunction in primary human hepatocytes in vitro; impact of C/EBPα-controlled gene expression
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Toxicology"
DOI: 10.1007/s00204-020-02835-x
Abstract: Valproic acid (VPA) is a frequently prescribed anti-epileptic drug which is known to cause liver toxicity and steatosis through mitochondrial dysfunction. Nevertheless the mechanisms underlying these adverse effects are incompletely understood. In this study, we… read more here.
Keywords: vpa exposure; gene; vpa; mitochondrial dysfunction ... See more keywords
5-HT7 receptor activation rescues impaired synaptic plasticity in an autistic-like rat model induced by prenatal VPA exposure
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2021.107462
Abstract: Autism spectrum disorder (ASD) is a severe life-long neuropsychiatric disorder. Alterations and imbalance of several neurochemical systems may be involved in ASD pathophysiology, of them, serotonergic neurotransmission dysfunction and deficiency may underlie behavioral abnormalities associated… read more here.
Keywords: vpa exposure; synaptic plasticity; autistic like; vpa ... See more keywords