Sex dependent alterations of resveratrol on social behaviors and nociceptive reactivity in VPA-induced autistic-like model in rats.
Sign Up to like & getrecommendations! Published in 2020 at "Neurotoxicology and teratology"
DOI: 10.1016/j.ntt.2020.106905
Abstract: INTRODUCTION The present study was designed to clarify the effects of resveratrol (RSV) on social behavioral alterations and nociceptive reactivity in valproic acid (VPA)-induced autistic-like model in female and male rats. METHODS Pregnant Wistar rats… read more here.
Keywords: nociceptive reactivity; vpa; male rats; autistic like ... See more keywords
The relationship between valproate induced tremors and circulating neurotransmitters: a preliminary study
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DOI: 10.1080/00207454.2016.1181631
Abstract: Patients with epilepsy and on valproate (VPA) therapy may develop tremors as a common adverse effect; however, its exact mechanisms are unknown. We hypothesize that VPA-induced tremors may be related to the disturbances in dopamine… read more here.
Keywords: relationship valproate; vpa therapy; vpa; vpa induced ... See more keywords
Postnatal treatment using curcumin supplements to amend the damage in VPA-induced rodent models of autism
Sign Up to like & getrecommendations! Published in 2017 at "BMC Complementary and Alternative Medicine"
DOI: 10.1186/s12906-017-1763-7
Abstract: BackgroundValproic acid (VPA) is used as a first-line antiepileptic agent and is undergoing clinical trials for use as a treatment for many disorders. Mothers undergoing VPA treatment during early pregnancy reportedly show increased rates of… read more here.
Keywords: rats group; vpa; vpa induced; treatment ... See more keywords
The Changes of Amygdala Transcriptome in Autism Rat Model After Arginine Vasopressin Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.838942
Abstract: Background Some studies have shown that arginine vasopressin (AVP) can significantly improve the social interaction disorder of autism, but the mechanism remains unclear. Methods Female Wistar rats were intraperitoneally injected with VPA or normal saline… read more here.
Keywords: autism model; vpa induced; model; autism ... See more keywords
The serum acylcarnitines profile in epileptic children treated with valproic acid and the protective roles of peroxisome proliferator-activated receptor a activation in valproic acid-induced liver injury
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1048728
Abstract: Valproic acid (VPA) is widely used as a major drug in the treatment of epilepsy. Despite the undisputed pharmacological importance and effectiveness of VPA, its potential hepatotoxicity is still a major concern. Being a simple… read more here.
Keywords: vpa; liver injury; vpa induced; epileptic children ... See more keywords