Preprint Highlight: ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA- dependent STING signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology of the cell"
DOI: 10.1091/mbc.p22-02-1003
Abstract: Loss-of-function mutations in VPS13C cause familial Parkinson’s disease (PD) and increase the risk to develop the sporadic form of the disease. However, the underlying disease mechanisms remain unclear. It has been previously established that VPS13C… read more here.
Keywords: transfer protein; highlight lysosome; lysosome lipid; vps13c ... See more keywords
Circ-VPS13C enhances cisplatin resistance in ovarian cancer via modulating miR-106b-5p/YWHAZ axis
Sign Up to like & getrecommendations! Published in 2021 at "Archives of Medical Science"
DOI: 10.5114/aoms/133038
Abstract: Introduction Ovarian cancer (OC) is the malignant tumor with the highest mortality among gynecological cancers. Chemotherapy resistance is a major obstacle to OC therapy. Circular RNAs (circRNAs) play crucial roles in cancer development and chemoresistance.… read more here.
Keywords: circ vps13c; resistance; vps13c; mir 106b ... See more keywords