Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29
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DOI: 10.1038/s41467-020-18773-2
Abstract: VARP and TBC1D5 are accessory/regulatory proteins of retromer-mediated retrograde trafficking from endosomes. Using an NMR/X-ray approach, we determined the structure of the complex between retromer subunit VPS29 and a 12 residue, four-cysteine/Zn++ microdomain, which we… read more here.
Keywords: varp; varp tbc1d5; mechanism evolution; fingernail ... See more keywords
VPS29 Exerts Opposing Effects on Endocytic Viral Entry
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DOI: 10.1128/mbio.03002-21
Abstract: These data identify a host pathway by which VPS29 and associated factors control the endosomal environment in a manner that influences susceptibility to viral infection. This pathway could serve as a pharmaceutical target for intervention… read more here.
Keywords: zoonotic viral; identify host; vps29; infection ... See more keywords