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   Articles with "vps34" as a keyword



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Schwann cell‐specific deletion of the endosomal PI 3‐kinase Vps34 leads to delayed radial sorting of axons, arrested myelination, and abnormal ErbB2‐ErbB3 tyrosine kinase signaling

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recommendations! Published in 2017 at "Glia"

DOI: 10.1002/glia.23173

Abstract: The PI 3‐kinase Vps34 (Pik3c3) synthesizes phosphatidylinositol 3‐phosphate (PI3P), a lipid critical for both endosomal membrane traffic and macroautophagy. Human genetics have implicated PI3P dysregulation, and endosomal trafficking in general, as a recurring cause of… read more here.

Keywords: vps34; schwann cell; kinase; myelination ... See more keywords
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ULK1 O-GlcNAcylation Is Crucial for Activating VPS34 via ATG14L during Autophagy Initiation.

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recommendations! Published in 2018 at "Cell reports"

DOI: 10.1016/j.celrep.2018.11.042

Abstract: Unc-51-like-kinase 1 (ULK1) is a target of both the mechanistic target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK), whose role is to facilitate the initiation of autophagy in response to starvation. Upon glucose starvation,… read more here.

Keywords: ulk1 glcnacylation; glcnacylation crucial; initiation; glcnacylation ... See more keywords

Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes

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recommendations! Published in 2021 at "Nature Communications"

DOI: 10.1038/s41467-021-21695-2

Abstract: The lipid phosphatidylinositol-3-phosphate (PI3P) is a regulator of two fundamental but distinct cellular processes, endocytosis and autophagy, so its generation needs to be under precise temporal and spatial control. PI3P is generated by two complexes… read more here.

Keywords: rab5; kinase; vps34; activation ... See more keywords
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Exploring the mechanism of trehalose: dual functions of PI3K/Akt and VPS34/mTOR pathways in porcine oocytes and cumulus cells†.

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recommendations! Published in 2022 at "Biology of reproduction"

DOI: 10.1093/biolre/ioac060

Abstract: Autophagy, an intracellular recycling system, is essential for the meiotic maturation of porcine oocytes. Multiple studies, sought to reveal the precise mechanism employed, commonly used autophagy inducers, such as rapamycin, which is a mammalian target… read more here.

Keywords: porcine oocytes; porcine; vps34; pi3k akt ... See more keywords
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VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney

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recommendations! Published in 2022 at "Science Signaling"

DOI: 10.1126/scisignal.abo7940

Abstract: The lipid kinase VPS34 orchestrates autophagy, endocytosis, and metabolism and is implicated in cancer and metabolic disease. The proximal tubule in the kidney is a key metabolic organ that controls reabsorption of nutrients such as… read more here.

Keywords: vps34; kidney; tubule; membrane ... See more keywords
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Class III PI3K Positively Regulates Platelet Activation and Thrombosis via PI(3)P-Directed Function of NADPH Oxidase

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recommendations! Published in 2017 at "Arteriosclerosis, Thrombosis, and Vascular Biology"

DOI: 10.1161/atvbaha.117.309751

Abstract: Objective— Class III phosphoinositide 3-kinase, also known as VPS34 (vacuolar protein sorting 34), is a highly conserved enzyme regulating important cellular functions such as NADPH oxidase (NOX) assembly, membrane trafficking, and autophagy. Although VPS34 is… read more here.

Keywords: class iii; platelet activation; vps34; activation ... See more keywords
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A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth.

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recommendations! Published in 2017 at "Blood"

DOI: 10.1182/blood-2017-04-781641

Abstract: To uncover the role of Vps34, the sole class III phosphoinositide 3-kinase (PI3K), in megakaryocytes (MKs) and platelets, we created a mouse model with Vps34 deletion in the MK/platelet lineage (Pf4-Cre/Vps34lox/lox). Deletion of Vps34 in… read more here.

Keywords: dual role; class iii; thrombus growth; vps34 ... See more keywords

The VPS34 PI3K negatively regulates RAB-5 during endosome maturation

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recommendations! Published in 2017 at "Journal of Cell Science"

DOI: 10.1242/jcs.194746

Abstract: ABSTRACT The GTPase Rab5 and phosphatidylinositol-3 phosphate [PI(3)P] coordinately regulate endosome trafficking. Rab5 recruits Vps34, the class III phosphoinositide 3-kinase (PI3K), to generate PI(3)P and recruit PI(3)P-binding proteins. Loss of Rab5 and loss of Vps34… read more here.

Keywords: rab5; pi3k; vps34; rab endosome ... See more keywords