VPS34 Governs Oocyte Developmental Competence by Regulating Mito/Autophagy: A Novel Insight into the Significance of RAB7 Activity and Its Subcellular Location
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202308823
Abstract: Asynchronous nuclear and cytoplasmic maturation in human oocytes is believed to cause morphological anomalies after controlled ovarian hyperstimulation. Vacuolar protein sorting 34 (VPS34) is renowned for its pivotal role in regulating autophagy and endocytic trafficking.… read more here.
Keywords: activity subcellular; governs oocyte; oocyte developmental; vps34 ... See more keywords
Schwann cell‐specific deletion of the endosomal PI 3‐kinase Vps34 leads to delayed radial sorting of axons, arrested myelination, and abnormal ErbB2‐ErbB3 tyrosine kinase signaling
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23173
Abstract: The PI 3‐kinase Vps34 (Pik3c3) synthesizes phosphatidylinositol 3‐phosphate (PI3P), a lipid critical for both endosomal membrane traffic and macroautophagy. Human genetics have implicated PI3P dysregulation, and endosomal trafficking in general, as a recurring cause of… read more here.
Keywords: vps34; schwann cell; kinase; myelination ... See more keywords
ULK1 O-GlcNAcylation Is Crucial for Activating VPS34 via ATG14L during Autophagy Initiation.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.11.042
Abstract: Unc-51-like-kinase 1 (ULK1) is a target of both the mechanistic target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK), whose role is to facilitate the initiation of autophagy in response to starvation. Upon glucose starvation,… read more here.
Keywords: ulk1 glcnacylation; glcnacylation crucial; initiation; glcnacylation ... See more keywords
Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21695-2
Abstract: The lipid phosphatidylinositol-3-phosphate (PI3P) is a regulator of two fundamental but distinct cellular processes, endocytosis and autophagy, so its generation needs to be under precise temporal and spatial control. PI3P is generated by two complexes… read more here.
Keywords: rab5; kinase; vps34; activation ... See more keywords
Exploring the mechanism of trehalose: dual functions of PI3K/Akt and VPS34/mTOR pathways in porcine oocytes and cumulus cells†.
Sign Up to like & getrecommendations! Published in 2022 at "Biology of reproduction"
DOI: 10.1093/biolre/ioac060
Abstract: Autophagy, an intracellular recycling system, is essential for the meiotic maturation of porcine oocytes. Multiple studies, sought to reveal the precise mechanism employed, commonly used autophagy inducers, such as rapamycin, which is a mammalian target… read more here.
Keywords: porcine oocytes; porcine; vps34; pi3k akt ... See more keywords
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney
Sign Up to like & getrecommendations! Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abo7940
Abstract: The lipid kinase VPS34 orchestrates autophagy, endocytosis, and metabolism and is implicated in cancer and metabolic disease. The proximal tubule in the kidney is a key metabolic organ that controls reabsorption of nutrients such as… read more here.
Keywords: vps34; kidney; tubule; membrane ... See more keywords
VPS34-mediated autophagosome-lysosome fusion facilitates classical swine fever virus replication
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Virology"
DOI: 10.1128/jvi.01641-25
Abstract: ABSTRACT Classical swine fever virus (CSFV) is a highly contagious and lethal pathogen that poses a major threat to the global swine industry. Despite its economic impact, no specific antiviral therapies are currently available, underscoring… read more here.
Keywords: replication; autophagosome lysosome; host; swine ... See more keywords
Class III PI3K Positively Regulates Platelet Activation and Thrombosis via PI(3)P-Directed Function of NADPH Oxidase
Sign Up to like & getrecommendations! Published in 2017 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.117.309751
Abstract: Objective— Class III phosphoinositide 3-kinase, also known as VPS34 (vacuolar protein sorting 34), is a highly conserved enzyme regulating important cellular functions such as NADPH oxidase (NOX) assembly, membrane trafficking, and autophagy. Although VPS34 is… read more here.
Keywords: class iii; platelet activation; vps34; activation ... See more keywords
A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2017-04-781641
Abstract: To uncover the role of Vps34, the sole class III phosphoinositide 3-kinase (PI3K), in megakaryocytes (MKs) and platelets, we created a mouse model with Vps34 deletion in the MK/platelet lineage (Pf4-Cre/Vps34lox/lox). Deletion of Vps34 in… read more here.
Keywords: dual role; class iii; thrombus growth; vps34 ... See more keywords
The VPS34 PI3K negatively regulates RAB-5 during endosome maturation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.194746
Abstract: ABSTRACT The GTPase Rab5 and phosphatidylinositol-3 phosphate [PI(3)P] coordinately regulate endosome trafficking. Rab5 recruits Vps34, the class III phosphoinositide 3-kinase (PI3K), to generate PI(3)P and recruit PI(3)P-binding proteins. Loss of Rab5 and loss of Vps34… read more here.
Keywords: rab5; pi3k; vps34; rab endosome ... See more keywords
NRBF2 plays a crucial role in the acquisition process of learning and memory, independent of the Vps34 complex
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2025.1529522
Abstract: Introduction NRBF2, a component of autophagy-associated PIK3C3/VPS34-containing phosphatidylinositol 3-kinase complex, plays a crucial role in learning and memory processes, yet its specific impact on memory and the underlying molecular mechanisms remains unclear. Methods Here, we… read more here.
Keywords: memory; role; acquisition; plays crucial ... See more keywords