Deciphering the role of VPS35 in Parkinson's disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24262
Abstract: Parkinson’s disease (PD), the most common neurodegenerative movement disorder, affects about 2% of the population over the age of 65. That percentage increases to about 5% in people over the age of 85 (Lang &… read more here.
Keywords: protein; d620n mutation; disease; d620n ... See more keywords
VPS35 regulates tau phosphorylation and neuropathology in tauopathy
Sign Up to like & getrecommendations! Published in 2019 at "Molecular psychiatry"
DOI: 10.1038/s41380-019-0453-x
Abstract: The vacuolar protein sorting 35 (VPS35) is a major component of the retromer recognition core complex which regulates intracellular protein sorting and trafficking. Deficiency in VPS35 by altering APP/Aβ metabolism has been linked to late-onset… read more here.
Keywords: tau; regulates tau; pathological tau; vps35 ... See more keywords
Microglial VPS35 deficiency regulates microglial polarization and decreases ischemic stroke-induced damage in the cortex
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-019-1633-y
Abstract: BackgroundVacuolar sorting protein 35 (VPS35), a critical component of retromer, is essential for selective endosome-to-Golgi retrieval of membrane proteins. It is highly expressed in microglial cells, in addition to neurons. We have previously demonstrated microglial… read more here.
Keywords: ischemic stroke; cortex; vps35; brain ... See more keywords
Parkinson’s disease–associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy
Sign Up to like & getrecommendations! Published in 2021 at "Translational Neurodegeneration"
DOI: 10.1186/s40035-021-00243-4
Abstract: Background Mitochondrial dysfunction plays a prominent role in the pathogenesis of Parkinson’s disease (PD), and several genes linked to familial PD, including PINK1 (encoding PTEN-induced putative kinase 1 [PINK1]) and PARK2 (encoding the E3 ubiquitin… read more here.
Keywords: mediated mitophagy; pink1; vps35; parkinson disease ... See more keywords
High expression levels of the D686N Parkinson's disease mutation in VPS35 induces α-synuclein-dependent toxicity in yeast
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2017.6551
Abstract: Parkinson's disease (PD) is a common neurodegenerative disorder that affects ~2% of the human population aged >65. α-synuclein serves a role in the pathogenesis of PD as it is a primary component of Lewy bodies,… read more here.
Keywords: expression levels; toxicity; vps35; parkinson disease ... See more keywords