Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1
Sign Up to like & getrecommendations! Published in 2020 at "Nature Microbiology"
DOI: 10.1038/s41564-020-0753-6
Abstract: To avoid innate sensing and immune control, human immunodeficiency virus type 1 (HIV-1) has to prevent the accumulation of viral complementary DNA species. Here, we show that the late HIV-1 accessory protein Vpu hijacks DNA… read more here.
Keywords: integration; vpu; dna repair; hiv ... See more keywords
HIV-1 Vpu restricts Fc-mediated effector functions in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1101/2022.02.21.481308
Abstract: Non-neutralizing antibodies (nnAbs) can eliminate HIV-1-infected cells via antibody-dependent cellular cytotoxicity (ADCC) and were identified as a correlate of protection in the RV144 vaccine trial. Fc-mediated effector functions of nnAbs were recently shown to alter… read more here.
Keywords: hiv vpu; vpu restricts; mediated effector; vpu ... See more keywords
Decreased, Deformed, Defective—How HIV-1 Vpu Targets Peroxisomes
Sign Up to like & getrecommendations! Published in 2020 at "mBio"
DOI: 10.1128/mbio.00967-20
Abstract: Peroxisomes are found in essentially all eukaryotic cells and have been described as important hubs in innate sensing and the induction of type III interferons upon viral infection. Nevertheless, it remains poorly investigated how viral… read more here.
Keywords: innate sensing; vpu; hiv; hiv vpu ... See more keywords
Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu To Protect HIV-1-Infected Cells from NK Cell Responses
Sign Up to like & getrecommendations! Published in 2019 at "mBio"
DOI: 10.1128/mbio.01113-19
Abstract: The restriction factor BST-2 and the NK cell ligands NTB-A and PVR are among a growing list of membrane proteins found to be downregulated by HIV-1 Vpu. BST-2 antagonism enhances viral release, while NTB-A and… read more here.
Keywords: ntb pvr; vpu; hiv; cell responses ... See more keywords
Requirement of a functional ion channel for Sindbis virus glycoprotein transport, CPV-II formation, and efficient virus budding
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010892
Abstract: Many viruses encode ion channel proteins that oligomerize to form hydrophilic pores in membranes of virus-infected cells and the viral membrane in some enveloped viruses. Alphavirus 6K, human immunodeficiency virus type 1 Vpu (HIV-Vpu), influenza… read more here.
Keywords: ion channel; vpu; formation; virus ... See more keywords
An Observational Study of Genetic Diversity of HIV-1 vpu in Rapid Progressors in India.
Sign Up to like & getrecommendations! Published in 2023 at "Current HIV research"
DOI: 10.2174/1570162x21666230221152633
Abstract: BACKGROUND The genetic diversity in HIV-1 genes affects viral pathogenesis in HIV-1 positive patients. Accessory genes of HIV-1, including vpu, are reported to play a critical role in HIV pathogenesis and disease progression. Vpu has… read more here.
Keywords: hiv; diversity hiv; genetic diversity; vpu ... See more keywords
Novel Compound Inhibitors of HIV-1NL4-3 Vpu
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14040817
Abstract: HIV-1 Vpu targets the host cell proteins CD4 and BST-2/Tetherin for degradation, ultimately resulting in enhanced virus spread and host immune evasion. The discovery and characterization of small molecules that antagonize Vpu would further elucidate… read more here.
Keywords: novel compound; inhibitors hiv; vpu; compound inhibitors ... See more keywords