PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09867-7
Abstract: Lentiviruses have evolved to acquire an auxiliary protein Vpx to counteract the intrinsic host restriction factor SAMHD1. Although Vpx is phosphorylated, it remains unclear whether such phosphorylation indeed regulates its activity toward SAMHD1. Here we… read more here.
Keywords: restriction; pim kinases; host; samhd1 ... See more keywords
HIV-2 Vpx neutralizes host restriction factor SAMHD1 to promote viral pathogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Scientific reports"
DOI: 10.1038/s41598-021-00415-2
Abstract: SAMHD1, a human host factor found in myeloid cells which restricts HIV-1 replication. It depletes the dNTPs pool for viral cDNA syntheses, thus preventing the viral replication in the cells. The viral accessory protein, Vpx,… read more here.
Keywords: samhd1; restriction factor; hiv; vpx ... See more keywords
HIV-2 Depletes CD4 T Cells through Pyroptosis despite Vpx-Dependent Degradation of SAMHD1
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Virology"
DOI: 10.1128/jvi.00666-19
Abstract: CD4 T cell depletion during HIV-1 infection involves the demise of bystander CD4 T cells due to abortive infection, viral DNA sensing, inflammasome assembly, and death by caspase-1-dependent pyroptosis. HIV-2 infection is associated with milder… read more here.
Keywords: hiv; infection; pyroptosis; vpx ... See more keywords
Binding to DCAF1 distinguishes TASOR and SAMHD1 degradation by HIV-2 Vpx.
Sign Up to like & getrecommendations! Published in 2021 at "PLoS pathogens"
DOI: 10.1371/journal.ppat.1009609
Abstract: Human Immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2) succeed to evade host immune defenses by using their viral auxiliary proteins to antagonize host restriction factors. HIV-2/SIVsmm Vpx is known for degrading SAMHD1, a… read more here.
Keywords: hiv vpx; degradation; tasor; vpx ... See more keywords