LRRC8A is dispensable for a variety of microglial functions and response to acute stroke
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24156
Abstract: Microglia, resident brain immune cells, are critical in orchestrating responses to central nervous system (CNS) injury. Many microglial functions, such as phagocytosis, motility and chemotaxis, are suggested to rely on chloride channels, including the volume‐regulated… read more here.
Keywords: cell; lrrc8a; lrrc8a dispensable; vrac ... See more keywords
LRRCA8A and ANO1 contribute to serum-induced VRAC in a Ca2+-dependent manners.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2020.04.003
Abstract: The volume-regulated anion channel (VRAC) plays a central role in maintaining cell volume in response to osmotic stress. Leucine-rich repeat-containing 8A (LRRC8A) was recently identified as an essential component of VRAC although other Cl- channels… read more here.
Keywords: lrrca8a ano1; activation vrac; serum; ca2 ... See more keywords
GlialCAM/MLC1 modulates LRRC8/VRAC currents in an indirect manner: Implications for megalencephalic leukoencephalopathy
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2018.07.031
Abstract: Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare type of leukodystrophy caused by mutations in either MLC1 or GLIALCAM genes. Previous work indicated that chloride currents mediated by the volume-regulated anion channel (VRAC) and… read more here.
Keywords: mlc1; megalencephalic leukoencephalopathy; vrac currents; glialcam mlc1 ... See more keywords
ATP-releasing SWELL1 channel in spinal microglia contributes to neuropathic pain
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.ade9931
Abstract: Following peripheral nerve injury, extracellular adenosine 5′-triphosphate (ATP)–mediated purinergic signaling is crucial for spinal cord microglia activation and neuropathic pain. However, the mechanisms of ATP release remain poorly understood. Here, we show that volume-regulated anion… read more here.
Keywords: neuropathic pain; vrac; microglia; channel ... See more keywords
Profiling Cisplatin Resistance in Head and Neck Cancer: A Critical Role of the VRAC Ion Channel for Chemoresistance
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13194831
Abstract: Simple Summary Treatment success of head and neck cancers (HNSCC) is often hindered by chemoresistance. In this study, next-generation sequencing transcriptomics and CRISPR/Cas9 knockout strategies were used to identify cisplatin resistance mechanisms and potential (personalized)… read more here.
Keywords: cisplatin; hnscc; resistance; role ... See more keywords
Absolute Protein Amounts and Relative Abundance of Volume-regulated Anion Channel (VRAC) LRRC8 Subunits in Cells and Tissues Revealed by Quantitative Immunoblotting
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20235879
Abstract: The volume-regulated anion channel (VRAC) plays an important role in osmotic cell volume regulation. In addition, it is involved in various physiological processes such as insulin secretion, glia-neuron communication and purinergic signaling. VRAC is formed… read more here.
Keywords: regulated anion; volume; channel; cell ... See more keywords
VI-116, A Novel Potent Inhibitor of VRAC with Minimal Effect on ANO1
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23095168
Abstract: Volume-regulated anion channel (VRAC) is ubiquitously expressed and plays a pivotal role in vertebrate cell volume regulation. A heterologous complex of leucine-rich repeat containing 8A (LRRC8A) and LRRC8B-E constitutes the VRAC, which is involved in… read more here.
Keywords: effect; potent; inhibitor; inhibitor vrac ... See more keywords